Protein MKNK1 map

Identifiers
MAP kinase interacting serine/threonine kinase 1
HUGO:MKNK1, HGNC:7110, ENTREZ:8569, GENECARDS:GC01M047023, UNIPROT:Q9BUB5

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / MITOCHONDRIA_OXIDATIVE_STRESS  map

References
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase. In vitro, Mnk1 rapidly phosphorylates eIF-4E at the physiologically relevant site, Ser209
PMID:9878069
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
Phosphorylation of eIF-4E is believed to enhance its affinity for the 5'-cap

MKNK1@Cytosol

References
em_emtc_emtc_re396( EMT Senescence  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase

MKNK1|​pho@Cytosol

References
em_emtc_emtc_re396( EMT Senescence  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase
em_emtc_emtc_re398( EMT Senescence  map ):
PMID:9878069
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
In vitro, Mnk1 rapidly phosphorylates eIF-4E at the physiologically relevant site, Ser209

Modifications:
In compartment: Cytosol
  1. MKNK1@Cytosol map
  2. MKNK1|​pho@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MKNK1@Cytosol map + ATP@Cytosol map → map MKNK1|​pho@Cytosol map + ADP@Cytosol map
    As Catalyser:
    1. EIF4E@Cytosol map → map EIF4E|​pho@Cytosol map