Identifiers
guanine nucleotide binding protein (G protein) beta polypeptide 1
HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873
guanine nucleotide binding protein (G protein) beta polypeptide 2
HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879
guanine nucleotide binding protein (G protein) beta polypeptide 3
HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520
guanine nucleotide binding protein (G protein) beta polypeptide 4
HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0
guanine nucleotide binding protein (G protein) beta 5
HUGO:GNB HGNC:4401 ENTREZ:10681 UNIPROT:O14775
guanine nucleotide binding protein (G protein) beta polypeptide 5
HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775
HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1
HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2
HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3
HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4
HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / HEDGEHOG 
 Survival   / WNT_CANONICAL 
 Survival   / WNT_NON_CANONICAL 

References
PMID:21640127
PMID:17430994

1. G_beta_*:​G_gamma_*@Cytoplasm
2. G_beta_*:​G_gamma_*@Cytoplasm
3. G_beta_*:​G_gamma_*:​PLC-_beta_*@Cytoplasm
4. G_beta_*:​G_gamma_*:​p101*:​p110_beta__gamma_*@Cytoplasm
5. GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm
6. G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6@Cytoplasm
7. DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm
8. FZD*:​GDP:​G_alpha_*:​G_beta_*:​G_gamma_*@Cytoplasm
9. FZD*:​GDP:​G_alpha_o*:​G_beta_*:​G_gamma_*@Cytoplasm
10. G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6:​PTH@Cytoplasm
11. GDP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1*@Cytoplasm
12. GDP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*@Cytoplasm
13. GTP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6|​S1544_pho|​T1548_pho@Cytoplasm
14. FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm
15. GTP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*:​_beta_-Arrestin*@Cytoplasm
16. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm
17. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm
18. CRIPTO-1*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm
19. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*:​p120*@Cytoplasm
20. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LGR5:​LRP5_6*:​RSPO1-4*:​WNT*:​p120*@Cytoplasm
21. CK1_epsilon_*:​CTHRC1:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm

1. G_beta_*:​G_gamma_*@Cytosol

1. G_beta_*:​G_gamma_*@Endoplasmic Reticulum

1. AMER1*:​CK1_gamma_*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
2. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
3. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
4. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
5. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
6. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
8. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome
9. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome

1. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae
2. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae
3. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae

1. G_beta_*:​G_gamma_*@Cytosol + p101*:​p110_beta__gamma_*@Cytosol → p101*:​p110_beta__gamma_*@Cytosol
2. G_alpha__sub_i_endsub_*:​Ligand@Cytosol → PTCH*@Cytosol + su_shh1_s_shh3_s60 + G_beta_*:​G_gamma_*@Cytosol + SMO@Cytosol
3. GRK*@Cytosol + G_beta_*:​G_gamma_*@Cytosol → su_shh1_s_shh3_s69
4. WNT*@default + CK1_epsilon_*:​E-Cadherin*:​LRP5_6*:​p120*@Vaceolae + FZD*:​GDP:​G_alpha_o*:​G_beta_*:​G_gamma_*@Cytoplasm + GTP@Vaceolae + PRR*@Cytoplasm → CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae + GDP@Vaceolae
5. DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm → AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae + GTP:​G_alpha_o*@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm
6. DVL*|​pho|​emp|​emp@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm + _beta_-Arrestin2*@Cytoplasm → DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm
7. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae → AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae
8. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
9. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
10. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
11. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
12. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
13. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome
14. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome → CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome + E-Cadherin*|​pho@Endosome + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
15. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome → AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome
16. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome → Recycling @Cytoplasm
17. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome → Degradation@Cytoplasm
18. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome → DVL*|​pho|​pho|​pho|​pho@Endosome + AMER1*:​CK1_gamma_*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
19. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm → LRP5_6*@Cytoplasm + E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm
20. LRP5_6*@Cytoplasm → E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm
21. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm → WNT canonical pathway@Cytoplasm
22. CRIPTO-1*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm → WNT canonical pathway@Cytoplasm
23. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm + CRIPTO-1*:​LRP5_6*@Cytoplasm → CRIPTO-1*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm
24. LGR5:​RSPO1-4*@Cytoplasm + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*:​p120*@Cytoplasm → CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LGR5:​LRP5_6*:​RSPO1-4*:​WNT*:​p120*@Cytoplasm
25. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LGR5:​LRP5_6*:​RSPO1-4*:​WNT*:​p120*@Cytoplasm → WNT canonical pathway@Cytoplasm
26. GDP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*@Cytoplasm → Apoptosis@Cytoplasm
27. G_beta_*:​G_gamma_*@Cytoplasm + IP3R*@Endoplasmic Reticulum → G_beta_*:​G_gamma_*@Endoplasmic Reticulum
28. G_beta_*:​G_gamma_*@Cytoplasm + p101*:​p110_beta__gamma_*@Cytoplasm → G_beta_*:​G_gamma_*:​p101*:​p110_beta__gamma_*@Cytoplasm
29. G_beta_*:​G_gamma_*:​p101*:​p110_beta__gamma_*@Cytoplasm → PI3K AKT MTOR pathway@Cytoplasm
30. GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm + LRP6@Cytoplasm → G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6@Cytoplasm
31. PTH@default + G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6@Cytoplasm + GTP@Cytoplasm → G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6:​PTH@Cytoplasm + GDP@Cytoplasm
32. G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6:​PTH@Cytoplasm → GTP:​G_alpha__sub_s_endsub_*@Cytoplasm + LRP6@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm + PTH@default
33. LRP6|​S1544_pho|​T1548_pho@Cytoplasm + GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm + GTP@Cytoplasm → GTP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6|​S1544_pho|​T1548_pho@Cytoplasm + GDP@Cytoplasm + LRP6|​S1544_pho|​T1548_pho@Cytoplasm
34. GTP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6|​S1544_pho|​T1548_pho@Cytoplasm → GTP:​G_alpha__sub_s_endsub_*@Cytoplasm + GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm
35. WNT*@default + FZD*:​GDP:​G_alpha_*:​G_beta_*:​G_gamma_*@Cytoplasm + GTP@Cytoplasm → FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm + GDP@Cytoplasm
36. FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm → G_beta_*:​G_gamma_*@Cytoplasm + GTP:​G_alpha_*@Cytoplasm
37. GTP:​G_alpha__sub_s_endsub_*@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm → GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm
38. G_beta_*:​G_gamma_*@Cytoplasm + PLC-_beta_*@Cytoplasm → G_beta_*:​G_gamma_*:​PLC-_beta_*@Cytoplasm
39. ROR2@Cytoplasm + FZD*:​GDP:​G_alpha_*:​G_beta_*:​G_gamma_*@Cytoplasm + WNT*@default + GTP@Cytoplasm + CK1_epsilon_*@Cytoplasm + CTHRC1@Cytoplasm + SYN4*@Cytoplasm + PAR6*:​PRICKLE1|​pho:​RACK1*:​VANGL*@Cytoplasm + PRR*@Cytoplasm → CK1_epsilon_*:​CTHRC1:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm + GDP@Cytoplasm
40. CK1_epsilon_*:​CTHRC1:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm → GTP:​G_alpha_*@Cytoplasm + CK1_epsilon_*:​CTHRC1:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm
41. GDP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1*@Cytoplasm → GDP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*@Cytoplasm
42. GDP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*@Cytoplasm + GTP@Cytoplasm + _beta_-Arrestin*@Cytoplasm → GTP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*:​_beta_-Arrestin*@Cytoplasm + GDP@Cytoplasm
43. GTP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*:​_beta_-Arrestin*@Cytoplasm → PAR1_sub_TRUNC_endsub_*@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm + GTP:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm

1. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae → AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae
2. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
3. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
4. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome
5. DVL*@Cytoplasm + CUL3:​KLHL*:​RBX1@Cytoplasm → CUL3:​DVL*:​KLHL*:​RBX1@Cytoplasm
6. JBN*:​_beta_-Catenin*@Cytoplasm → JBN*:​_beta_-Catenin*@Cilium
7. JBN*:​_beta_-Catenin*@Cilium → su_wca1_s_wca1_s764
8. ATP6V0C_D*@Vaceolae → ATP6V0C_D*@Vaceolae
9. AKT1@Cytoplasm → AKT1|​pho@Cytoplasm
10. DVL*@Cytoplasm → DVL*|​pho|​S142_emp|​S139_emp@Cytoplasm
11. PI4,5-P2@Cytoplasm → DAG@Cytoplasm + IP3@Cytoplasm
12. Ca2+@Endoplasmic Reticulum → Ca2+@Cytoplasm
13. GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm + LRP6@Cytoplasm → G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6@Cytoplasm