Protein SMO map

Identifiers
HUGO:SMO
Smoothened
HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

References
CASCADE:HH
PMID:20215540
SMO is upregulated in pancreatic CAFs
AFs expressing SMO could transduce the Sonic hedgehog signal to activate Gli1 expression, and small interfering RNA knockdown of SMO blocked the induction of Gli1 in these cells.
PMID:23031257
TGF-??1???Induced Fibroblast Differentiation Depends on SMO in Control Fibroblasts
Expression of collagen and actin (alphaSMA) and FN1 are SMO and GLI1/GLI2 dependent
PMID:19081070
The Hh reception system consists of a 12-span transmembrane protein, Patched (Ptc), as the Hh receptor and a 7-span transmembrane protein, Smoothened (Smo), as the obligatory signal transducer across the plasma membrane (Ingham and McMahon, 2001). In the absence of Hh, Ptc blocks Smo activity, and full-length Gli proteins are proteolytically processed to generate C-terminally truncated GliR that actively represses a subset of Hh target genes. Hh binding to Ptc unleashes Smo activity, which blocks GliR production and promotes GliA activation.
PMID:18820483
PMID:17641202
Smoothened homologue (Drosophila)

SMO|​pho|​active@Primary Cilium

References
s_shh1_re38( Survival  map ):
PMID:20956384
PMID:21209912
PMID:19549984
PMID:19592253
s_shh1_re40( Survival  map ):
PMID:20643644
s_shh1_re52:( Survival  map ) PMID:20016067
s_shh1_re92:( Survival  map ) PMID:18997815
s_shh1_re101:( Survival  map ) PMID:17688959
su_shh1_s_shh1_re40( Survival  map ):

SMO|​pho|​active@Cytosol

References
s_shh1_re28:( Survival  map ) PMID:15618519
s_shh3_re8( Survival  map ):
PMID:18815277
PMID:16885213
s_shh1_re33:( Survival  map ) PMID:18497258
s_shh3_re13:( Survival  map ) PMID:12514186 PMID:18359851

SMO@Extracellular space

References
su_shh1_s_shh2_re121( Survival  map ):
PMID:20564213
ANNOTATION: Not clear how suprresion is regulated by Hedgehog
su_shh1_s_shh2_re122:( Survival  map ) PMID:19351822

SMO|​pho|​active@Cytosol

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

Modifications:
In compartment: Cytosol
  1. SMO@Cytosol map
  2. SMO|​pho|​active@Cytosol map
  3. SMO|​pho|​active@Cytosol map
In compartment: Extracellular space
  1. SMO@Extracellular space map
In compartment: Primary Cilium
  1. SMO|​pho|​active@Primary Cilium map
Participates in complexes:
In compartment: Clathrin-coated vesicle
  1. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Clathrin-coated vesicle map
In compartment: Cytosol
  1. PTCH*:​SMO@Cytosol map
In compartment: Primary Cilium
  1. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Primary Cilium map
Participates in reactions:
As Reactant or Product:
  1. PTCH*:​SMO@Cytosol map → map SMO@Cytosol map + PTCH*@Cytosol map
  2. G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​HH Ligand@Cytosol map → map su_shh1_s635 + SMO@Cytosol map + su_shh1_s_shh1_s589 + G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*@Cytosol map
  3. SMO@Cytosol map → map SMO|​pho|​active@Cytosol map
  4. SMO|​pho|​active@Cytosol map + _beta_-Arrestin2*@Cytosol map + KIF3A:​KIF3B@Cytosol map → map KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Clathrin-coated vesicle map
  5. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Primary Cilium map → map _beta_-Arrestin2*@Primary Cilium map + SMO|​pho|​active@Primary Cilium map + KIF3A:​KIF3B@Primary Cilium map
  6. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Clathrin-coated vesicle map → map KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Primary Cilium map
  7. G_alpha__sub_i_endsub_*:​Ligand@Cytosol map → map PTCH*@Cytosol map + su_shh1_s_shh3_s60 + G_beta_*:​G_gamma_*@Cytosol map + SMO@Cytosol map
  8. SMO@Cytosol map → map SMO|​pho|​active@Cytosol map
  9. SMO|​pho|​active@Cytosol map → map Sonic hedgehog pathway@Cytosol map
As Catalyser:
  1. gGLI1@Cytosol map → map rGLI1@Cytosol map
  2. gGLI2@Cytosol map → map rGLI2@Cytosol map
  3. gGLI3@Cytosol map → map rGLI3@Cytosol map
  4. AKT*|​pho|​pho:​PI3,4,5-P3@Cytosol map → map AKT*|​pho|​pho|​pho:​PI3,4,5-P3@Cytosol map
  5. GLI2-185*:​KIF7:​SUFU:​ULK3@Cytosol map → map GLI2-185*:​KIF7:​SUFU:​ULK3@Primary Cilium map
  6. GLI3-190*|​S849_emp:​KIF7:​SUFU:​ULK3@Cytosol map → map GLI3-190*|​S849_emp:​KIF7:​SUFU:​ULK3@Primary Cilium map
  7. GLI2-185*:​KIF7:​SUFU:​ULK3@Primary Cilium map → map SUFU@Primary Cilium map + GLI2-185*@Primary Cilium map + KIF7@Primary Cilium map + ULK3@Primary Cilium map
  8. GLI3-190*|​S849_emp:​KIF7:​SUFU:​ULK3@Primary Cilium map → map SUFU@Primary Cilium map + GLI3-190*|​S849_emp|​active@Primary Cilium map + KIF7@Primary Cilium map + ULK3@Primary Cilium map
  9. AKAP*@Primary Cilium map + PKA*@Primary Cilium map → map AKAP*:​PKA*@Primary Cilium map
  10. SUFU@Cytosol map → map SUFU|​K257_ubi@Cytosol map
  11. gMIR29B*@Nucleus map → map arMIR29B*@Nucleus map
  12. gMIR378@Nucleus map → map arMIR378@Nucleus map
  13. C-FES*@Cytosol map → map C-FES*@Cytosol map