Protein GRK* map

Identifiers
adrenergic beta receptor kinase 1
HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098
adrenergic beta receptor kinase 2
HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626
G protein-coupled receptor kinase 1
HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1
G protein-coupled receptor kinase 4
HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4
G protein-coupled receptor kinase 5
HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5
G protein-coupled receptor kinase 6
HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6
G protein-coupled receptor kinase 7
HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7
HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1
HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map
 Survival  map  / HEDGEHOG  map

References
Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN.
PMID:11226259
PMID:16525728
PMID:15618519

GRK*@Cytoplasm

References
su_mpk1_mpk1_re85( Survival  map ):
Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN.
PMID:11226259

GRK*@Cytosol

References
s_shh1_re115( Survival  map ):
PMID:12764189
PMID:18815277
s_mpk1_re85( Survival  map ):
Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN.
PMID:11226259

Modifications:
In compartment: Cytoplasm
  1. GRK*@Cytoplasm map
In compartment: Cytosol
  1. GRK*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. GRK*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*@Cytosol map
In compartment: Early Endosomes
  1. GPCR*:​GRK*@Early Endosomes map
  2. ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map
In compartment: Plasma Membrane
  1. GPCR*|​pho:​GRK*@Plasma Membrane map
  2. GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map
Participates in reactions:
As Reactant or Product:
  1. GPCR*|​pho:​GRK*@Plasma Membrane map + _beta_-Arrestin2*@Cytoplasm map → map GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map
  2. GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map + ERK*@Cytoplasm map + RAF1@Cytoplasm map + MEK*@Cytoplasm map → map ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map
  3. GPCR*@Plasma Membrane map + GRK*@Cytoplasm map → map GPCR*|​pho:​GRK*@Plasma Membrane map
  4. ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map → map GPCR*:​GRK*@Early Endosomes map + ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map + RAF1@Cytoplasm map
  5. GRK*@Cytosol map + G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*@Cytosol map → map GRK*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*@Cytosol map
  6. GRK*@Cytosol map + G_beta_*:​G_gamma_*@Cytosol map → map su_shh1_s_shh3_s69
As Catalyser:
  1. SMO@Cytosol map → map SMO|​pho|​active@Cytosol map