Identifiers
HUGO:AKT1 HUGO:AKT2 HUGO:AKT3
v-akt murine thymoma viral oncogene homolog 1
HUGO:AKT1, HGNC:391, ENTREZ:207, UNIPROT:P31749, GENECARDS:GC14M105235
HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749
HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / MITOCHONDRIA_OXIDATIVE_STRESS 
 EMT Senescence   / SENESCENCE 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / PI3K_AKT_MTOR 
 Survival   / WNT_NON_CANONICAL 

References
PMID:20214616
PMID:17680028
PMID:20398329

References
mo_re4:( motility  ) PMID:17409395 PMID:21084277 PMID:19440036 PMID:19945467 PMID:20609352 PMID:26597054 PMID:23572150 PMID:27328425 PMID:27572739 PMID:25136802 PMID:24030100
mo_re5:( motility  ) PMID:21084277 PMID:19945467
mo_re12:( motility  ) PMID:17409395 PMID:19440036 PMID:23572150
mo_re38:( motility  ) PMID:18471976 PMID:19945467 PMID:27328425
mo_re51:( motility  ) PMID:23589069 PMID:22131018 PMID:29556339
mo_re152:( motility  ) PMID:19930715 PMID:26597054 PMID:27572739 PMID:27510662
mo_re177:( motility  ) PMID:26597054 PMID:27328425
mo_re251:( motility  ) PMID:27328425 PMID:27572739 PMID:27510662

References
mo_re4:( motility  ) PMID:17409395 PMID:21084277 PMID:19440036 PMID:19945467 PMID:20609352 PMID:26597054 PMID:23572150 PMID:27328425 PMID:27572739 PMID:25136802 PMID:24030100

References
mo_re229:( motility  ) PMID:25897829

References
mo_re229:( motility  ) PMID:25897829

References
s_akt1_re24:( Survival  ) PMID:18042541 PMID:18077353

References
s_akt1_re40:( Survival  ) PMID:19662498

References
s_akt1_re40:( Survival  ) PMID:19662498
s_akt1_re41( Survival  ):
PMID:19662498
PMID:19387550
PMID:18566586

References
s_akt1_re103:( Survival  ) PMID:11154281
s_akt1_re119( Survival  ):
PMID:15169778
PMID:11923280
PMID:11715018

References
s_wnc1_re1( Survival  ):
PMID:21506126
PAR1 can induce AKT phosphorylation; exact mechanism unknown also wich residues are unknown
PMID:17374729
s_wnc1_re23:( Survival  ) PMID:9859994

References
s_wnc1_re1( Survival  ):
PMID:21506126
PAR1 can induce AKT phosphorylation; exact mechanism unknown also wich residues are unknown
PMID:17374729
s_wnc1_re2( Survival  ):
Phosphorylation of beta-catenin is through an indirect mechanism which is unknown
PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE
su_wnc1_s_wnc1_re2( Survival  ):

References
s_wnc1_re23:( Survival  ) PMID:9859994
s_wnc1_re123( Survival  ):
Akt phosphorylates POSH in the Rac1 binding domain, preventing binding of Rac1 w/ POSH
PMID:17535800

1. AKT1@Cytoplasm
2. AKT1|​pho@Cytoplasm
3. AKT1|​pho|​active@Cytoplasm
4. AKT1|​T450_pho|​S473_emp|​active@Cytoplasm
5. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm
6. AKT1|​T450_emp|​S473_emp|​S129_pho@Cytoplasm

1. AKT1@Cytosol
2. AKT1|​ser473_pho|​active@Cytosol

1. AKT1@Nucleus
2. AKT1|​ser473_pho|​active@Nucleus
3. AKT1|​T308_pho|​T450_pho|​S473_pho|​active@Nucleus

1. AKT1|​T450_emp|​S473_emp|​S129_pho:​HSP90*@Cytoplasm

1. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft
2. AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft

1. AKT1@Cytosol → Apoptosis@Cytosol
2. AKT1@Cytosol → NF-_kappa_B_p65*@Cytosol
3. AKT1@Cytosol → AKT1@Cytosol
4. AKT1|​ser473_pho|​active@Cytosol → Proliferation@Cytosol
5. AKT1|​ser473_pho|​active@Nucleus → AKT1@Nucleus
6. AKT1|​ser473_pho|​active@Cytosol → EMT & motility@Cytosol
7. AKT1@Cytosol → AKT1|​ser473_pho|​active@Cytosol
8. AKT1|​ser473_pho|​active@Cytosol → Stress-induced apoptosis resistance@Cytosol
9. AKT1@Cytosol → cleaved~AKT1*@Cytosol
10. AKT1@Cytosol → AKT*@Cytosol
11. rAKT1@Nucleus → AKT1@Cytosol
12. AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft → AKT1|​T308_pho|​T450_pho|​S473_pho|​active@Nucleus
13. AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft → AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft
14. PI3,4,5-P3@Lipid Raft + AKT1|​T450_pho|​S473_emp|​active@Cytoplasm → AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft
15. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft → AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft
16. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm → AKT1|​T450_pho|​S473_emp|​active@Cytoplasm
17. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft → AKT1|​T450_pho|​S473_emp|​active@Cytoplasm
18. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm → AKT1|​T450_emp|​S473_emp|​S129_pho@Cytoplasm
19. AKT1|​T450_emp|​S473_emp|​S129_pho@Cytoplasm + HSP90*@Cytoplasm → AKT1|​T450_emp|​S473_emp|​S129_pho:​HSP90*@Cytoplasm
20. AKT1|​T450_emp|​S473_emp|​S129_pho:​HSP90*@Cytoplasm → AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft
21. AKT1@Cytoplasm → AKT1|​pho@Cytoplasm
22. AKT1@Cytoplasm → AKT1|​pho|​active@Cytoplasm
23. AKT1|​pho|​active@Cytoplasm → PI3K AKT MTOR pathway@Cytoplasm

1. MDM2@Nucleus → MDM2|​S186_pho@Nucleus
2. BAD@Mitochondria → BAD|​pho@Mitochondria
3. FOXO3@Nucleus → FOXO3|​pho@Nucleus
4. rp21CIP1*@Nucleus → p21CIP1*@Cytosol
5. GSK3_beta_*@Cytosol → GSK3_beta_*|​S_pho@Cytosol
6. GSK3??*@Cytosol → GSK3??*|​Ser9_pho@Cytosol
7. gMMP2@Nucleus → rMMP2@Nucleus
8. TSC1:​TSC2@Lysosome → TSC1:​TSC2|​S939_pho@Lysosome
9. gMMP9@Nucleus → rMMP9@Nucleus
10. FOXO*@Cytosol → FOXO*|​pho@Cytosol
11. rp21CIP1*@Nucleus → p21CIP1*@Nucleus
12. p21CIP1*@Cytosol → p21CIP1*|​pho@Cytosol
13. MDM2@Cytosol → MDM2|​pho|​active@Cytosol
14. gMMP7@Nucleus → rMMP7@Nucleus
15. FOXO3|​S315_pho@Nucleus → FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus
16. GSK3_beta_*@Cytoplasm → GSK3_beta_*|​pho@Cytoplasm
17. MDM2|​S166_emp@Cytoplasm → MDM2|​S166_pho|​pho@Cytoplasm
18. MDM2|​S166_pho|​pho@Nucleus → MDM2|​S166_pho|​pho|​S188_pho@Nucleus
19. su_akt1_s_akt1_s533 → su_akt1_s_akt1_s528
20. 14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria → 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria
21. ENOS*@Cytoplasm → ENOS*|​pho@Cytoplasm
22. Caspase9*@Cytoplasm → Caspase9*|​pho@Cytoplasm
23. p21CIP1*@Cytoplasm → p21CIP1*|​T145_pho@Cytoplasm
24. p21CIP1*|​T145_pho@Cytoplasm → p21CIP1*|​T145_pho|​T146_pho@Cytoplasm
25. CUL1:​RBX1:​RICTOR@Cytoplasm → CUL1:​RBX1:​RICTOR|​T1135_pho@Cytoplasm
26. PI3,4,5-P3@Lipid Raft + AKT1|​T450_pho|​S473_emp|​active@Cytoplasm → AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft
27. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft → AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft
28. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft → AKT1|​T450_pho|​S473_emp|​active@Cytoplasm
29. TSC1:​TSC2@Endosome Membrane → TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane
30. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
31. p27KIP1*|​S10_pho@Cytoplasm → p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm
32. POSH*@Cytoplasm → POSH*|​S304_pho@Cytoplasm
33. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*|​S522_pho@Cytoplasm