Identifiers
low density lipoprotein receptor-related protein 6
HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 
 Survival   / WNT_NON_CANONICAL 

References
su_wnc1_s_wnc1_re38:( Survival  ) PMID:21406690
su_wnc1_s_wnc1_re44( Survival  ):
PKA phosphorylates first Thr1548? followed by GSK3 at S1544
PMID:21406690
su_wnc1_s_wnc1_re47:( Survival  ) PMID:21237163
su_wca1_s_wca2_re55:( Survival  ) PMID:21536646

References
s_wnc1_re45:( Survival  ) PMID:21406690

References
s_wnc4_re6( Survival  ):
Phosphorylation of LRP6 by ERKk and simultanious activation by Wnt3 gives a higher activation rate of the canoncical wnt pathway (synergetic effect)
PMID:22558232

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 

References
s_wca2_re60( Survival  ):
Without RIPK4 upon wnt3 stimulation 25% of HeLa cells show DVL2 in puncta. Co-transfection of RIPK4 increases this number to more than 75%
PMID:23371553

1. LRP6@Cytoplasm
2. LRP6@Cytoplasm
3. LRP6@Cytoplasm
4. LRP6|​S1490_pho|​T1572_pho@Cytoplasm
5. LRP6|​S1544_pho|​T1548_pho@Cytoplasm

1. CCN2*:​LRP6@Cytoplasm
2. CK1*:​LRP6:​TMEM198@Cytoplasm
3. DVL2|​S480_pho|​S298_pho:​LRP6:​RIPK4@Cytoplasm
4. CK1*:​LRP6|​T1479_pho|​pho|​T1493_pho:​TMEM198@Cytoplasm
5. G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6@Cytoplasm
6. G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6:​PTH@Cytoplasm
7. GTP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6|​S1544_pho|​T1548_pho@Cytoplasm

1. TMEM198@Cytoplasm + LRP6@Cytoplasm + CK1*@Cytoplasm → CK1*:​LRP6:​TMEM198@Cytoplasm
2. CK1*:​LRP6:​TMEM198@Cytoplasm → CK1*:​LRP6|​T1479_pho|​pho|​T1493_pho:​TMEM198@Cytoplasm
3. CK1*:​LRP6|​T1479_pho|​pho|​T1493_pho:​TMEM198@Cytoplasm → WNT canonical pathway@Cytoplasm
4. DVL2|​S480_pho|​S298_pho:​RIPK4@Cytoplasm + LRP6@Cytoplasm → DVL2|​S480_pho|​S298_pho:​LRP6:​RIPK4@Cytoplasm
5. DVL2|​S480_pho|​S298_pho:​LRP6:​RIPK4@Cytoplasm → WNT canonical pathway@Cytoplasm
6. GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm + LRP6@Cytoplasm → G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6@Cytoplasm
7. PTH@default + G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6@Cytoplasm + GTP@Cytoplasm → G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6:​PTH@Cytoplasm + GDP@Cytoplasm
8. G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6:​PTH@Cytoplasm → GTP:​G_alpha__sub_s_endsub_*@Cytoplasm + LRP6@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm + PTH@default
9. LRP6@Cytoplasm → LRP6|​S1544_pho|​T1548_pho@Cytoplasm
10. LRP6|​S1544_pho|​T1548_pho@Cytoplasm + GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm + GTP@Cytoplasm → GTP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6|​S1544_pho|​T1548_pho@Cytoplasm + GDP@Cytoplasm + LRP6|​S1544_pho|​T1548_pho@Cytoplasm
11. GTP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6|​S1544_pho|​T1548_pho@Cytoplasm → GTP:​G_alpha__sub_s_endsub_*@Cytoplasm + GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm
12. LRP6@Cytoplasm + CCN2*@default → CCN2*:​LRP6@Cytoplasm
13. CCN2*:​LRP6@Cytoplasm → WNT canonical pathway@Cytoplasm
14. LRP6@Cytoplasm → LRP6|​S1490_pho|​T1572_pho@Cytoplasm
15. LRP6|​S1490_pho|​T1572_pho@Cytoplasm → WNT canonical pathway@Cytoplasm

1. GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm + LRP6@Cytoplasm → G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6@Cytoplasm
2. LRP6|​S1544_pho|​T1548_pho@Cytoplasm + GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm + GTP@Cytoplasm → GTP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6|​S1544_pho|​T1548_pho@Cytoplasm + GDP@Cytoplasm + LRP6|​S1544_pho|​T1548_pho@Cytoplasm