Protein PTCH* map

Identifiers
HUGO:PTCH1 HUGO:PTCH2
patched 1
HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635
HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1
Patched 2
HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

References
CASCADE:HH
PMID:19081070
The Hh reception system consists of a 12-span transmembrane protein, Patched (Ptc), as the Hh receptor and a 7-span transmembrane protein, Smoothened (Smo), as the obligatory signal transducer across the plasma membrane (Ingham and McMahon, 2001). In the absence of Hh, Ptc blocks Smo activity, and full-length Gli proteins are proteolytically processed to generate C-terminally truncated GliR that actively represses a subset of Hh target genes. Hh binding to Ptc unleashes Smo activity, which blocks GliR production and promotes GliA activation.
PMID:20495383
PMID:19465923
PMID:22679284
Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9
PMID:10021362
PMID:17641202

PTCH*@Primary Cilium

References
s_shh1_re85:( Survival  map ) PMID:11331587
s_shh1_re49( Survival  map ):
PMID:20016067
the PTC receptor itself does not trigger the activation of PKA but the withdrawal of the SHH ligand does
PMID:16537363

Modifications:
In compartment: Cytosol
  1. PTCH*@Cytosol map
In compartment: Primary Cilium
  1. PTCH*@Primary Cilium map
Participates in complexes:
In compartment: Cytosol
  1. PTCH*:​SMO@Cytosol map
In compartment: Primary Cilium
  1. CyclinB*:​PTCH*@Primary Cilium map
  2. HH Ligand:​PTCH*@Primary Cilium map
Participates in reactions:
As Reactant or Product:
  1. rPTCH*@Cytosol map → map PTCH*@Cytosol map
  2. PTCH*:​SMO@Cytosol map → map SMO@Cytosol map + PTCH*@Cytosol map
  3. PTCH*@Cytosol map + DRAL*@Cytosol map + TUCAN*@Cytosol map + NLRP1@Cytosol map + NEDD4@Cytosol map → map DRAL*:​NEDD4:​NLRP1:​TUCAN*@Cytosol map
  4. rc_s5785 → map SHH@Extracellular space map + PTCH*@Cytosol map
  5. CDO*:​HH Ligand@Primary Cilium map → map HH Ligand:​PTCH*@Primary Cilium map
  6. GAS1:​HH Ligand@Primary Cilium map → map HH Ligand:​PTCH*@Primary Cilium map
  7. BOC:​HH Ligand@Primary Cilium map → map HH Ligand:​PTCH*@Primary Cilium map
  8. HH Ligand@default map + PTCH*@Primary Cilium map → map HH Ligand:​PTCH*@Primary Cilium map
  9. HH Ligand:​PTCH*@Primary Cilium map → map su_shh1_s635
  10. PTCH*@Primary Cilium map + CyclinB*@Primary Cilium map → map CyclinB*:​PTCH*@Primary Cilium map
  11. CyclinB*:​PTCH*@Primary Cilium map → map CyclinB*@Primary Cilium map + PTCH*@Primary Cilium map
  12. Ligand@Cytosol map + PTCH*@Cytosol map → map su_shh1_s_shh3_s6
  13. PTCH*@Cytosol map + DRAL*@Cytosol map + TUCAN*@Cytosol map + Caspase9*@Cytosol map → map su_shh1_s_shh3_s137
  14. G_alpha__sub_i_endsub_*:​Ligand@Cytosol map → map PTCH*@Cytosol map + su_shh1_s_shh3_s60 + G_beta_*:​G_gamma_*@Cytosol map + SMO@Cytosol map
As Catalyser:
  1. AKAP*:​PKA*@Primary Cilium map → map PKA*@Primary Cilium map + AKAP*@Primary Cilium map
  2. CyclinB*:​PTCH*@Primary Cilium map → map CyclinB*@Primary Cilium map + PTCH*@Primary Cilium map