Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 

References
Apoptosis
su_mpk1_mpk1_re214( Survival  ):
A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release.
PMID:12107820
su_mpk1_mpk1_re241( Survival  ):
Activated caspase-9 cleaves and activates caspase-3 leading to apoptosis.
PMID:9390557
su_mpk1_mpk1_re276( Survival  ):
In response to genotoxic stress such as DNA damage PUMA is transactivated by P53 (leading to apoptosis).
PMID:19641508
su_mpk1_mpk1_re277( Survival  ):
FOXO3a promotes apoptosis through activation of PUMA.
PMID:20978166
su_wnc1_s_wnc1_re21( Survival  ):
PAR1 silencing leads to increased protein level of activated caspase3 and 9. Increased protein level of Bim, Bax
PMID:17374729
su_wnc1_s_wnc4_re43( Survival  ):
transcription-independent apc-mediated apoptosis
PMID:19900451, PMID:17297457

References
s_wnc2_re80:( Survival  ) PMID:16648474

References
su_wnc1_s_wnc4_re10:( Survival  ) PMID:15526030
su_shh1_s_shh2_re114:( Survival  ) PMID:18379348

References
s_wnc4_re10:( Survival  ) PMID:15526030

References
s_shh2_re114:( Survival  ) PMID:18379348

1. Apoptosis@Cytoplasm
2. Apoptosis@Cytoplasm
3. Apoptosis@Cytoplasm

1. Apoptosis@Cytosol

1. Apoptosis@Mitochondria
2. Apoptosis@Mitochondria

1. Apoptosis@Nucleus
2. Apoptosis@Nucleus
3. Apoptosis@Nucleus

1. DR4/5*:​THBS1:​TRAIL*@Cytosol → Apoptosis@Cytosol
2. BAD@Cytosol → Apoptosis@Cytosol
3. Apoptosis@Cytosol → Survival@Cytosol
4. Survivin*@Cytosol → Apoptosis@Cytosol
5. AKT1@Cytosol → Apoptosis@Cytosol
6. BAD:​BAD_binding partners*@Mitochondria → Apoptosis@Cytosol
7. MAP3K5@Cytosol → Apoptosis@Cytosol
8. BBC3@Mitochondria → Apoptosis@Cytosol
9. BAX:​p53*@Cytosol → Apoptosis@Cytosol
10. BAK1:​p53*@Mitochondria → Apoptosis@Cytosol
11. EMT@Cytosol → Apoptosis@Cytosol
12. XIAP@Cytosol → Apoptosis@Cytosol
13. Senescence@Cytosol → Apoptosis@Cytosol
14. Apoptosis@Cytosol → Cell cycle / survival / proliferation@Cytosol
15. p38 MAPK*|​pho|​active@Cytosol → Apoptosis@Cytosol
16. CHOP*|​pho@Nucleus → Apoptosis@Cytosol
17. BAX|​S163_pho|​active@Cytosol → Apoptosis@Cytosol
18. Apoptosis@Cytosol → Cell death@Cytosol
19. XIAP@Cytosol → Apoptosis@Cytosol
20. ATG5:​CASP8|​K63_ubi:​FADD:​LC3*:​SQSTM1 @Autophgosome → Apoptosis@Cytosol
21. BCL2L11|​S58_pho|​active@Cytosol → Apoptosis@Cytosol
22. BID|​pho|​active@Cytosol → Apoptosis@Cytosol
23. cleaved~Caspase3*@Cytosol → Apoptosis@Cytosol
24. cleaved~Caspase9*@Cytosol → Apoptosis@Cytosol
25. su_akt1_s_akt1_s533 → Apoptosis@Mitochondria
26. Caspase9__sub_TRUNC_endsub_*@Cytoplasm → Apoptosis@Mitochondria
27. Caspase3*@Cytoplasm → Apoptosis@Mitochondria
28. BAD@Mitochondria → Apoptosis@Cytoplasm
29. Caspase3_sub_TRUNC_endsub_*@Cytoplasm → Apoptosis@Cytoplasm
30. p53*|​pho@Nucleus → Apoptosis@Cytoplasm
31. FOXO3|​pho@Nucleus → Apoptosis@Cytoplasm
32. rFUS@Nucleus → Apoptosis@Nucleus
33. Trail pathway@Nucleus → Apoptosis@Nucleus
34. HIPK2@Nucleus → Apoptosis@Nucleus
35. GDP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*@Cytoplasm → Apoptosis@Cytoplasm
36. MOMP@Mitochondria → Apoptosis@Mitochondria
37. p38*@Cytoplasm → Apoptosis@Mitochondria
38. JNK*@Cytoplasm → Apoptosis@Mitochondria
39. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus → Apoptosis@Nucleus
40. Caspase8_sub_TRUNC_endsub_*@Cytoplasm → Apoptosis@Cytoplasm
41. Apoptosis@Cytoplasm → Caspase3_sub_TRUNC_endsub_*@Cytoplasm
42. APC_sub_TRUNC_endsub_*@Mitochondria → Apoptosis@Cytoplasm