References
PMID:10811803 PMID:10089876 PMID:7650486 PMID:9973469 PMID:15214048
ad_re340:( Adaptive Immune Response  ) PMID:12740575 PMID:15972651

References
PMID:10811803 PMID:10089876 PMID:7650486 PMID:9973469 PMID:15214048
ad_re340:( Adaptive Immune Response  ) PMID:12740575 PMID:15972651

References
mo_re203:( motility  ) PMID:23572150

Identifiers
CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8

Identifiers
CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8

References
CASCADE:Fc_gamma_RIII
 NATURAL_KILLER 
PMID:16204312
Calcium influx is an early event during perforin-mediated cytotoxicity.
PMID:12740575, PMID:15972651
NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.
Calcium influx is an early event during perforin-mediated cytotoxicity. PLC-??2 is absolutely required to regulate degranulation of cytotoxic perforin granules.
PMID:22683124
PLCG2-deficient NK cells displayed a partial reduction of conjugate formationwith target tumor cells probably via regulation of Ca2+ fluxes,
because a chelator of intracellular Ca2+ also provokes a partial reduction of conjugate formation.
PMID:10089876, PMID:7650486, PMID:9973469
??Ca('2+)??activates Calmodulin 2 (??Calmodulin??)/ Protein phosphatase 3 (Calcineurin??) signal. Activated??Calcineurin??dephosphorylates Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2 (??NF-AT1(NFATC2)??).??
(PMID10089876). This signaling is activated downstream of CD16
in_re177( Innate Immunity  ):
In NK cells NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.
in_re1( Innate Immunity  ):
PMID:10837075
Immature DCs are very efficient in Ag capture and can use several pathways, such as (a) macropinocytosis; (b) receptor-mediated endocytosis via C-type lectin receptors (mannose receptor, DEC-205)
or Fc?? receptor types I (CD64) and II (CD32) [uptake of immune complexes or opsonized particles ]; and (c) phagocytosis of particles such as latex beads , apoptotic and necrotic cell fragments (involving CD36 and ??v??3 or ??v??5 integrins), viruses, and bacteria including mycobacteria, as well as intracellular parasites such as Leishmania major. DCs can also internalize the peptide loaded heat shock proteins gp96 and Hsp70 through presently unknown mechanisms
in_re1145( Innate Immunity  ):
PMID:7890616
Intracellular Ca2+??release induces cAMP Accumulation in Human Monocytes and activation of PKA signaling downstream of IL13.

Identifiers
Ca2+
CAS:N/A PUBCHEM:N/A CHEBI:39124 KEGGCOMPOUND:N/A

References
Calcium liberated from internal stores by IP3 acts on the calcium- and DAG-sensitive RasGRP1 and causes it to translocate to the Golgi.
PMID:16488589
su_mpk1_mpk1_re42( Survival  ):
IP3 diffuses through the cytosol and binds to receptors on the endoplasmic reticulum causing the release of calcium ions (Ca2+) into the cytosol.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html
su_wnc1_s_wnc1_re27:( Survival  ) PMID:12747838
su_mpk1_mpk1_re50( Survival  ):
Calcium activates the Ras GAP CAPRI (RASA4) that translocates to the PM and downregulates any Ras that is activated on this compartment by the exchange factor SOS.
su_mpk1_mpk1_re263( Survival  ):
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
PMID:15567848
su_wnc1_s_wnc1_re159( Survival  ):
PMID:21670566
PMID:17593948
There are more mechanisms to activate Calpain
PMID:16129881
su_wnc1_s_wnc1_re160:( Survival  ) PMID:19725819
su_wnc1_s_wnc2_re25( Survival  ):
Formation is dependent of Ca2+ concentration. It is believed that Ca2+ concentration regulates activity of Calpastatin.
PMID:12684003
su_wnc1_s_wnc2_re46( Survival  ):
Upon Ca2+ activation the NRON-NFAT complex dissociates.
PMID:21709260

References
Ca2+/Wnt MODULE

1. Ca2+@Cytoplasm
2. Ca2+@Cytoplasm
3. Ca2+@Cytoplasm

1. Ca2+@Cytosol
2. Ca2+@Cytosol

1. Ca2+@Endopasmic Reticulum

1. Ca2+@Endoplasmic Reticulum

1. Ca2+@INNATE_IMMUNE_CELL_Cytosol

1. Ca2+@Mitochondria inner membrane

1. Ca2+@T_cell

1. Ca2+@default

1. CASR:​Ca2+@Cytoplasm
2. Ca2+:​Calmodulin*@Cytoplasm
3. Ca2+:​Calmodulin*@Cytoplasm
4. CAMK2*:​Ca2+:​Calmodulin*@Cytoplasm
5. CAMK2*:​Ca2+:​Calmodulin*@Cytoplasm
6. Ca2+:​Calmodulin*:​PPP3R*@Cytoplasm
7. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm
8. Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm
9. Ca2+:​Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB:​PPP3R*@Cytoplasm
10. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
11. CSE1L:​Ca2+:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm

1. Ca2+:​Calmodulin*@Cytosol
2. CAMK2*:​Ca2+:​Calmodulin*@Cytosol

1. BiP*:​Ca2+:​Grp75*:​ITPR*:​SIGMAR1:​VDAC*@Endopasmic Reticulum

1. Ca2+:​DAG:​RASGRP1@Golgi Apparatus
2. Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus
3. Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus

1. Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol
2. CNA*:​CNB*:​Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol

1. CALR:​Ca2+@Mitochondria inner membrane

1. CAPN1:​Ca2+@Mitochondrial intermembrane space

1. Ca2+:​Calmodulin*@Nucleus
2. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Nucleus
3. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus

1. Ca2+:​DAG:​PKC*@Plasma Membrane
2. Ca2+:​DAG:​RASGRP1@Plasma Membrane

1. Ca2+:​Calmodulin*@T_cell
2. CNA*:​CNB*:​Ca2+:​Calmodulin*@T_cell

1. Ca2+@Endoplasmic Reticulum → Ca2+@T_cell
2. Ca2+@T_cell + Calmodulin*@T_cell → Ca2+:​Calmodulin*@T_cell
3. Ca2+:​Calmodulin*@T_cell + CNA*:​CNB*@T_cell → CNA*:​CNB*:​Ca2+:​Calmodulin*@T_cell
4. Ca2+@INNATE_IMMUNE_CELL_Cytosol → EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane
5. Ca2+@Endoplasmic Reticulum → Ca2+@INNATE_IMMUNE_CELL_Cytosol
6. Ca2+@INNATE_IMMUNE_CELL_Cytosol → Conjugate_formation@INNATE_IMMUNE_CELL_Membrane
7. Ca2+@INNATE_IMMUNE_CELL_Cytosol + Calmodulin*@INNATE_IMMUNE_CELL_Cytosol → Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol
8. Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol + CNA*:​CNB*@INNATE_IMMUNE_CELL_Cytosol → CNA*:​CNB*:​Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol
9. Ca2+@Cytosol → Ca2+@Cytosol
10. Ca2+@Cytosol + Calmodulin*@Cytosol → Ca2+:​Calmodulin*@Cytosol
11. CAMK2*@Cytosol + Ca2+:​Calmodulin*@Cytosol → CAMK2*:​Ca2+:​Calmodulin*@Cytosol
12. CAMK2*:​Ca2+:​Calmodulin*@Cytosol → EMT & motility@Cytosol
13. Ca2+@Cytosol + NOX5@Cytosol → rc_s4240
14. Ca2+@Cytosol + CAPN1@Cytosol → rc_s5229
15. Ca2+ Wave@Cytosol → Ca2+@Cytosol
16. Ca2+@Endopasmic Reticulum → Ca2+@Cytosol
17. Ca2+@Cytosol → Oxidative phosphorylation@Cytosol
18. Ca2+@Endopasmic Reticulum → BiP*:​Ca2+:​Grp75*:​ITPR*:​SIGMAR1:​VDAC*@Endopasmic Reticulum
19. CALR@Mitochondria inner membrane + Ca2+@Mitochondria inner membrane → CALR:​Ca2+@Mitochondria inner membrane
20. Ca2+@Endopasmic Reticulum → Ca2+@Cytosol
21. Ca2+@Cytosol → high Ca2+ cytosol level@Cytosol
22. Ca2+@Cytosol → release of ER Ca2+@Cytosol
23. Ca2+@Cytosol → Ca2+@Endopasmic Reticulum
24. Grp75*@Endopasmic Reticulum + BiP*:​SIGMAR1@Endopasmic Reticulum + Ca2+@Endopasmic Reticulum + ITPR*@Cytosol + VDAC*@Cytosol → BiP*:​Ca2+:​Grp75*:​ITPR*:​SIGMAR1:​VDAC*@Endopasmic Reticulum
25. CAPN1@Cytosol + Ca2+@Cytosol → rc_s7547
26. PKC*@Cytoplasm + DAG@Plasma Membrane + Ca2+@Cytoplasm → Ca2+:​DAG:​PKC*@Plasma Membrane
27. RAS*@Plasma Membrane + Ca2+:​DAG:​RASGRP1@Golgi Apparatus → Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus
28. IP3@Endoplasmic Reticulum → Ca2+@Cytoplasm
29. DAG:​RASGRP1@Plasma Membrane + Ca2+@Cytoplasm → Ca2+:​DAG:​RASGRP1@Plasma Membrane
30. Ca2+:​DAG:​RASGRP1@Plasma Membrane → Ca2+:​DAG:​RASGRP1@Golgi Apparatus
31. RAF1@Cytoplasm + Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus → Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus
32. Calmodulin*@Cytoplasm + Ca2+@Cytoplasm → Ca2+:​Calmodulin*@Cytoplasm
33. CAMK2*@Cytoplasm + Ca2+:​Calmodulin*@Cytoplasm → CAMK2*:​Ca2+:​Calmodulin*@Cytoplasm
34. Ca2+@Endoplasmic Reticulum → Ca2+@Cytoplasm
35. CAMK2*:​Ca2+:​Calmodulin*@Cytoplasm → MAPK pathway@Cytoplasm
36. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm + NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm → Ca2+:​Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB:​PPP3R*@Cytoplasm
37. Ca2+:​Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB:​PPP3R*@Cytoplasm → Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm
38. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm → Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus
39. Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm + KPNB1@Cytoplasm + Tubulin-_alpha_*@Cytoplasm + TNPO1@Cytoplasm → Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
40. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm + LRRK2@Cytoplasm + rNRON@Cytoplasm + CSE1L@Cytoplasm → CSE1L:​Ca2+:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
41. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm → Ca2+:​Calmodulin*:​PPP3R*@Cytoplasm
42. Ca2+@default + CASR@Cytoplasm → CASR:​Ca2+@Cytoplasm
43. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus → NFAT*@Nucleus + Tubulin-_alpha_*@Nucleus + Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Nucleus + KPNB1@Nucleus
44. PPP3CB:​PPP3R*@Cytoplasm + Ca2+:​Calmodulin*@Cytoplasm → Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm

1. NFAT*|​pho@T_cell → NFAT*@T_cell
2. CAMK2*@T_cell → CAMK2*|​pho|​active@T_cell
3. BCL10|​pho@T_cell → BCL10@T_cell
4. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR → Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
5. ATP@INNATE_IMMUNE_CELL_Cytosol → cAMP@INNATE_IMMUNE_CELL_Cytosol
6. NFAT*|​pho@INNATE_IMMUNE_CELL_Cytosol → NFAT*@INNATE_IMMUNE_CELL_Cytosol
7. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol → Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol
8. gNFAT*@INNATE_IMMUNE_CELL_Cytosol → rNFAT*@INNATE_IMMUNE_CELL_Cytosol
9. GSK3??*@Cytosol → GSK3??*|​Ser9_pho@Cytosol
10. gE-cadherin*@Nucleus → rE-cadherin*@Nucleus
11. Snail*|​pho@Nucleus → Snail*@Nucleus
12. AKT1@Cytosol → AKT1|​ser473_pho|​active@Cytosol
13. Ca2+@Endopasmic Reticulum → BiP*:​Ca2+:​Grp75*:​ITPR*:​SIGMAR1:​VDAC*@Endopasmic Reticulum
14. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol → AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytosol
15. AIFM1@Mitochondrial inner membrane → cleaved~AIFM1*@Mitochondrial intermembrane space
16. AIFM1|​don@Mitochondrial inner membrane → cleaved~AIFM1*@Mitochondrial intermembrane space
17. GRB2:​SOS*@Cytoplasm + RTK*@Plasma Membrane → GRB2:​RTK*:​SOS*@Plasma Membrane
18. RAF1@Cytoplasm → RAF1|​pho@Cytoplasm
19. RTK*@Plasma Membrane + SRC@Cytoplasm → RTK*:​SRC@Plasma Membrane
20. RASA4@Cytoplasm → RASA4@Plasma Membrane
21. ERK*:​MEK*:​SEF*@Golgi Apparatus → ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm
22. Calpain*@Cytoplasm → Calpain*@Cytoplasm
23. AKT1@Cytoplasm → AKT1|​pho|​active@Cytoplasm
24. PKC*@Cytoplasm → PKC*@Cytoplasm
25. Calpain*@Cytoplasm + Calpastatin*|​pho@Cytoplasm → Calpain*:​Calpastatin*|​pho@Cytoplasm
26. 14-3-3*:​BAD|​pho|​pho|​pho@Cytoplasm → 14-3-3*:​BAD|​pho|​pho@Cytoplasm
27. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*|​S552_pho@Cytoplasm
28. CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm → NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm + IQGAP*@Cytoplasm + DYRK*@Cytoplasm + CK1_epsilon_*@Cytoplasm + rNRON@Cytoplasm + GSK3*@Cytoplasm
29. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm → Ca2+:​Calmodulin*:​PPP3R*@Cytoplasm
30. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm → TAB1:​TAB2:​TAK1*|​emp@Cytoplasm
31. MEF2*|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm → MEF2*@Cytoplasm
32. estrogen@Nucleus + ER_alpha_*@Nucleus + gERE@Nucleus + NFAT*@Nucleus + FOXA*@Nucleus → ERE:​ER_alpha_*:​FOXA*:​NFAT*@Nucleus