Protein _beta_-Arrestin* map

Identifiers
arrestin, beta 1
HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1
arrestin, beta 2
HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_NON_CANONICAL  map

_beta_-Arrestin*@Cytoplasm

References
s_wnc1_re8:( Survival  map ) PMID:11694535
s_wnc1_re152( Survival  map ):
Binding of beta-arrestin to PTEN increases the lipid phosphatase activity of PTEN which converts PIP3 to PIP2. Active ROCK stimulates this complex formation
PMID:21642958
ROCK phosphorylates PTEN which is than activated. Activated PTEN reduces the concentration of PIP3
PMID:15793569
PMID:20008297

Modifications:
In compartment: Cytoplasm
  1. _beta_-Arrestin*@Cytoplasm map
Participates in complexes:
In compartment: Cytoplasm
  1. PTEN|​pho|​pho|​pho|​pho:​_beta_-Arrestin*@Cytoplasm map
  2. GTP:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  3. G_alpha__sub_13q_endsub_*:​PLC-_beta_*:​_beta_-Arrestin*@Cytoplasm map
  4. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  5. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  6. GTP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*:​_beta_-Arrestin*@Cytoplasm map
Participates in reactions:
As Reactant or Product:
  1. GTP:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map + DVL*|​pho|​S142_emp|​S139_emp@Cytoplasm map → map DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  2. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map → map DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  3. PTEN|​pho|​pho|​pho|​pho:​_beta_-Arrestin*@Cytoplasm map → map PI3K AKT MTOR pathway@Cytoplasm map
  4. _beta_-Arrestin*@Cytoplasm map + PTEN@Cytoplasm map → map PTEN|​pho|​pho|​pho|​pho:​_beta_-Arrestin*@Cytoplasm map
  5. PTEN|​pho|​pho|​pho|​pho:​_beta_-Arrestin*@Cytoplasm map → map Cell migration@Nucleus map
  6. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map → map _beta_-catenin stability@Nucleus map
  7. GTP:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map + PLC-_beta_*@Cytoplasm map → map G_alpha__sub_13q_endsub_*:​PLC-_beta_*:​_beta_-Arrestin*@Cytoplasm map
  8. GTP:​G_alpha_*@Cytoplasm map → map GTP:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  9. GDP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*@Cytoplasm map + GTP@Cytoplasm map + _beta_-Arrestin*@Cytoplasm map → map GTP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*:​_beta_-Arrestin*@Cytoplasm map + GDP@Cytoplasm map
  10. GTP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*:​_beta_-Arrestin*@Cytoplasm map → map PAR1_sub_TRUNC_endsub_*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map + GTP:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
As Catalyser:
  1. PI4,5-P2@Cytoplasm map → map DAG@Cytoplasm map + IP3@Cytoplasm map