Protein JAK2 map

Identifiers
HUGO:JAK2

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:14610620
JAK2 is a member of the Janus kinase family.
JAK2 associated with IL13RA1 participates in signal transduction.
PMID: PMID:19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2
PMID:20406969, PMID:24091328, PMID:11867689
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation, probably downstream of JAK2. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.

JAK2@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. JAK2@Cytosol map
In compartment: Membrane
  1. JAK2@Membrane map
Participates in complexes:
In compartment: Membrane
  1. CSF2:​CSF2RA:​CSF2RB:​JAK2@Membrane map
  2. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
  3. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@Membrane map
  4. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
  5. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL4@default map + IL2RG:​IL4R@Membrane map + JAK3@Cytosol map + JAK2@Cytosol map + JAK1@Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@Membrane map
  2. IL13@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
  3. IL4@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
  4. CSF2@default map + CSF2RA:​CSF2RB@Membrane map + JAK2@Membrane map → map CSF2:​CSF2RA:​CSF2RB:​JAK2@Membrane map
  5. JAK2@Cytosol map + JAK1@Cytosol map + IFNGR1:​IFNGR2@Membrane map + IFNG|​hm2@default map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
As Catalyser:
  1. gTNF@Cytosol map → map rTNF@Cytosol map
  2. rIL12p35*@Cytosol map → map IL12p35*@Cytosol map
  3. NFKBIA|​pho@Cytosol map → map degraded
  4. rMHC class II*@Cytosol map → map MHC class II*@Cytosol map
  5. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  6. IRS2@Cytosol map → map IRS2|​pho@Cytosol map
  7. gTIMP3@Cytosol map → map rTIMP3@Cytosol map
  8. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  9. NFKB1_p50*@Cytosol map → map NFKB1_p50*|​hm2@Cytosol map
  10. gVEGFA@Cytosol map → map rVEGFA@Cytosol map
  11. HIF1A@Cytosol map → map HIF1A@Cytosol map
  12. gVEGFR1*@Cytosol map → map rVEGFR1*@Cytosol map
  13. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map
  14. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  15. rIL23A@Cytosol map → map IL23A@Cytosol map
  16. RELA@Cytosol map + NFKB1_p50*@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map
  17. STAT5*@Cytosol map → map STAT5*|​pho@Cytosol map