Protein STAT6 map

Identifiers
HUGO:STAT6

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
IL-4, in contrast to IL-13, induced very low levels of phosphorylation of Stats 1 and 5 and a more robust phosphorylation of Stat3 and Stat6.
PMID:23124025
Jak1 is required for Stat6 (TYR641) activation in monocytes stimulated with IL-4
PMID:14610620
When the type I
or type II IL-4R is dimerized, JAKs associated with
the receptor components phosphorylate the second,
third, or fourth tyrosine residues of the IL-4Ra cytoplasmic domain [50]. This phosphorylation recruits
Stat6, which is then also phosphorylated. PhosphoStat6 molecules dimerize and migrate to the nucleus to
bind to certain promoters.
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:15634881
STAT6-deficient mice produce M1 macrophages.
STAT6 deficiency prevents signaling through the type 2 IL-4Ralpha, thereby blocking the production of arginase and promoting the synthesis of NO in MDSC.

STAT6|​pho|​active@Cytosol

Identifiers

Maps_Modules

References

STAT6@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. STAT6@Cytosol map
  2. STAT6|​pho|​active@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. PPARG:​STAT6|​pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map
  2. PPARG@Cytosol map + STAT6|​pho|​active@Cytosol map → map PPARG:​STAT6|​pho@Cytosol map
  3. rSTAT6@Cytosol map → map STAT6@Cytosol map
As Catalyser:
  1. gARG1@Cytosol map → map rARG1@Cytosol map
  2. gIL13RA2@Cytosol map → map rIL13RA2@Cytosol map
  3. L-arginine@Cytosol map → map Urea@Cytosol map + L-ornitine@Cytosol map
  4. gMHC class II*@Cytosol map → map rMHC class II*@Cytosol map
  5. gALOX15@Cytosol map → map rALOX15@Cytosol map
  6. gMAOA@Cytosol map → map rMAOA@Cytosol map
  7. gCD36@Cytosol map → map rCD36@Cytosol map
  8. gDUSP1@Cytosol map → map rDUSP1@Cytosol map
  9. gPPARG@Cytosol map → map rPPARG@Cytosol map
  10. gMRC1@Cytosol map → map rMRC1@Cytosol map
  11. gKDM6B@Cytosol map → map rKDM6B@Cytosol map
  12. gHIF2A*@Cytosol map → map rHIF2A*@Cytosol map
  13. gCD209@Cytosol map → map rCD209@Cytosol map
  14. gKLF4@Cytosol map → map rKLF4@Cytosol map
  15. gNOS2@Cytosol map → map rNOS2@Cytosol map