Protein STAT5*
HUGO:STAT5A
HUGO:STAT5B
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
PMID:20406969, PMID:24091328, PMID:11867689
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation, probably downstream of JAK2. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.
PMID:24091328
G-CSF downregulates IRF8 expression via STAT3 and GM-CSF via STAT5. IRF8 inhibition provides immunosuppressive functions of MDSC.

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Modifications:
In compartment: Cytosol

1. STAT5*@Cytosol
2. STAT5*|​pho@Cytosol

Participates in complexes:

Participates in reactions:
As Reactant or Product:

1. STAT5*@Cytosol → STAT5*|​pho@Cytosol

As Catalyser:

1. gIRF8@Cytosol → rIRF8@Cytosol