Protein RELA map

Identifiers
HUGO:RELA

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:CORE_SIGNALING_PATHWAYS

References
PMID: PMID:19171876
NFkB signaling via RELA:p50 heterodimer provides
expression of proinflamatory cytokines and realisation
of M1 phenotype of macrophages.
PMID:17550372, PMID:9743347
IL13 inhibits NF??B activation via inhibition of p65 nuclear migration in inflammatory marophages
PMID:10521409, PMID:18802069
The endogenous IKK complex, overexpressed IKKs, and recombinant IKKbeta efficiently phosphorylated the Ser536 residue of p65 in vivo and in vitro,
that is important foe NFKB signaling activation. Ser536 is phoshorylated downstream of RAGE signaling in MDSC.

RELA@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. RELA@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CBP*:​RELA@Cytosol map
  2. NFKB1_p50*:​RELA|​pho@Cytosol map
  3. NFKB1_p50*:​NFKBIA:​RELA@Cytosol map
  4. NFKB1_p50*:​NFKBIA|​pho:​RELA|​pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NFKB1_p50*:​NFKBIA:​RELA@Cytosol map → map NFKB1_p50*:​NFKBIA|​pho:​RELA|​pho@Cytosol map
  2. rRELA@Cytosol map → map RELA@Cytosol map
  3. NFKB1_p50*:​NFKBIA|​pho:​RELA|​pho@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map + NFKBIA|​pho@Cytosol map
  4. RELA@Cytosol map + NFKB1_p50*@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map
  5. NFKB1_p50*:​RELA|​pho@Cytosol map + NFKBIA@Cytosol map → map NFKB1_p50*:​NFKBIA:​RELA@Cytosol map
  6. CBP*@Cytosol map + RELA@Cytosol map → map CBP*:​RELA@Cytosol map
  7. NFKB1_p50*:​RELA|​pho@Cytosol map → map M1 phenotype of macrophages@Cytosol map
As Catalyser:
  1. gTNF@Cytosol map → map rTNF@Cytosol map
  2. gIL13RA2@Cytosol map → map rIL13RA2@Cytosol map
  3. gABCB1@Cytosol map → map rABCB1@Cytosol map
  4. gIL1B@Cytosol map → map rIL1B@Cytosol map
  5. gCD40@Cytosol map → map rCD40@Cytosol map
  6. gNFKBIA@Cytosol map → map rNFKBIA@Cytosol map
  7. gPTGS2@Cytosol map → map rPTGS2@Cytosol map
  8. RELA@Cytosol map + NFKB1_p50*@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map
  9. gIL12p40*@Cytosol map → map rIL12p40*@Cytosol map
  10. gIL8*@Cytosol map → map rIL8*@Cytosol map
  11. gIL6@Cytosol map → map rIL6@Cytosol map
  12. gNOS2@Cytosol map → map rNOS2@Cytosol map