Reaction state_transition re318 map

STAT1@Cytosol map → STAT1|​pho|​active@Cytosol map

Reaction regulators:
Catalysis
  1. p38*|​pho|​active@Cytosol map
  2. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
Unknown_inhibition
  1. SMAD3|​pho:​SMAD4@Cytosol map
  2. SMAD2|​pho:​SMAD4@Cytosol map





Identifiers

Maps_Modules

References
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID: PMID:19833085
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.