STAT3

Protein STAT3

Identifiers
HUGO:STAT3

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:???21115385, PMID:7543512
???The binding of IL-10 to its receptor activates JAK1
Two tyrosines??? (???Tyr??? ???446??? ???and Tyr??? ???496???) ???of IL-10RA
are phosphorylated by the JAK1,??? ???to which
the transcription factor STAT3??? ???binds via its SH2??? ???domain
and in turn becomes itself phosphorylated.
PMID:10347215
Only JAK1/STAT3 pathway (but not TYK) plays role in
anti-inflammatory action of IL10 in macrophages.
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
IL-4, in contrast to IL-13, induced very low levels of phosphorylation of Stats 1 and 5 and a more robust phosphorylation of Stat3 and Stat6.
PMID:23124025
Stat3 activation (tyr 705) by IL-4 requires Jak1 kinase in monocytes
PMID:15218058
Stat3 binds ILR1N promoter and upregulates expression of IL1RN downstream of IL10
PMID:14607900
FNG inhibits IL10 signalind via STAT1.
STAT1 overexpression prevents STAT3 homodimerization.
PMID:23454751
MDSC showed high phosphorylated STAT3 levels that correlated with arginase-I expression levels and activity.
phosphorylated STAT3 binds to multiple sites in the arginase-I promoter. Rescue of arginase-I activity after STAT3 blockade restored MDSC???s suppressive function.
Taken together, these results demonstrate that the suppressive function of arginase-I in both infiltrating and circulating MDSC is a downstream target of activated STAT3.
PMID:20581311
STAT3 as an essential mediator of emergency granulopoiesis by its regulation of transcription factors that direct G-CSF-responsive myeloid progenitor expansion.
STAT3 directly controls G-CSF-dependent expression of CCAAT-enhancer-binding protein ?? (C/EBP??), a crucial factor in the emergency granulopoiesis response. Moreover, STAT3 and C/EBP?? coregulate c-Myc through interactions with the c-myc promoter that control the duration of C/EBP?? occupancy during demand-driven granulopoiesis.
PMID:19380816
MDSC-induced immune suppression is mediated by reactive oxygen species (ROS).
STAT3 mediates the function of MDSCs by regulating NADPH oxidase (NOX2) expression
In the absence of NOX2 activity, MDSC lost the ability to suppress T cell responses
PMID:20093776
IL6 signaling ilduces STAT3 phosphorylation in MDSC cells.
PMID:20406969
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.
PMID:18776941
Expression of VEGF and bFGF, but also IL-1??, MMP9, CCL2, and CXCL2 is STAT3-dependent in myeloid cells.

STAT3|pho|hm2|active@Cytosol

Identifiers

Maps_Modules

References

STAT3|pho|active@Cytosol

Identifiers
HUGO:STAT3

Maps_Modules
MODULE:MACROPHAGE

STAT3@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol

STAT3@Cytosol
STAT3|pho|active@Cytosol
STAT3|pho|hm2|active@Cytosol

Participates in complexes:

Participates in reactions:
As Reactant or Product:

As Catalyser: