Protein NFKB1_p50* map

Identifiers
HUGO:NFKB1

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:CORE_SIGNALING_PATHWAYS

References
PMID:19171876, PMID:17145890
NFkB p50/p50 homodimers (which lack the transactivation
domain) compete with canonical p65/p50 heterodimers for
the binding sites on the inflammatory
gene promoters, thereby blocking p65/p50 promoter
binding and gene transcription.
p50 NF-kappaB overexpression accounts for the
inability of tumor assasiated macrophages to mount
an effective M1 antitumor response capable of inhibiting tumor growth.

NFKB1_p50*|​hm2@Cytosol

Identifiers

Maps_Modules

References

NFKB1_p50*@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. NFKB1_p50*@Cytosol map
  2. NFKB1_p50*|​hm2@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. BCL3:​NFKB1_p50*|​hm2@Cytosol map
  2. NFKB1_p50*:​RELA|​pho@Cytosol map
  3. NFKB1_p50*:​NFKBIA:​RELA@Cytosol map
  4. NFKB1_p50*:​NFKBIA|​pho:​RELA|​pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NFKB1_p50*@Cytosol map → map NFKB1_p50*|​hm2@Cytosol map
  2. BCL3@Cytosol map + NFKB1_p50*|​hm2@Cytosol map → map BCL3:​NFKB1_p50*|​hm2@Cytosol map
  3. NFKB1_p50*|​hm2@Cytosol map → map M2 phenotype of macrophages_or_MDSC@Membrane map
  4. NFKB1_p50*:​NFKBIA:​RELA@Cytosol map → map NFKB1_p50*:​NFKBIA|​pho:​RELA|​pho@Cytosol map
  5. NFKB1_p50*:​NFKBIA|​pho:​RELA|​pho@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map + NFKBIA|​pho@Cytosol map
  6. RELA@Cytosol map + NFKB1_p50*@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map
  7. NFKB1_p50*:​RELA|​pho@Cytosol map + NFKBIA@Cytosol map → map NFKB1_p50*:​NFKBIA:​RELA@Cytosol map
  8. NFKB1_p50*:​RELA|​pho@Cytosol map → map M1 phenotype of macrophages@Cytosol map
As Catalyser:
  1. gTNF@Cytosol map → map rTNF@Cytosol map
  2. gIL13RA2@Cytosol map → map rIL13RA2@Cytosol map
  3. gABCB1@Cytosol map → map rABCB1@Cytosol map
  4. gIL1B@Cytosol map → map rIL1B@Cytosol map
  5. gCD40@Cytosol map → map rCD40@Cytosol map
  6. gNFKBIA@Cytosol map → map rNFKBIA@Cytosol map
  7. gPTGS2@Cytosol map → map rPTGS2@Cytosol map
  8. gIL12p40*@Cytosol map → map rIL12p40*@Cytosol map
  9. gIL8*@Cytosol map → map rIL8*@Cytosol map
  10. gIL6@Cytosol map → map rIL6@Cytosol map
  11. gNOS2@Cytosol map → map rNOS2@Cytosol map
  12. gBCL3@Cytosol map → map rBCL3@Cytosol map