Complex IL13:IL13RA1:IL4R:JAK1:JAK2:TYK2 map
Complex composition:

  1. IL13 map
  2. JAK1 map
  3. IL4R map
  4. IL13RA1 map
  5. JAK2 map
  6. TYK2 map

IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane

Identifiers
NAME:IL13:IL13RA1:IL4R:JAK1:JAK2:TYK2

Maps_Modules
MODULE:MACROPHAGE

References
PMID:14610620, PMID:12223527
IL13 acts via IL4 receptor type 2, which contains two subunits IL4R and IL13RA1
PMID:14610620, PMID:12223527, PMID:20510870
JAK1 associated with IL4R and JAK2 or TYK associated with IL13RA1 participate in signal transduction; They phosphorylate the second,
third, or fourth tyrosine residues of the IL-4Ra cytoplasmic domain.
PMID:23124025
IL13 signaling aktivates JAK2 and TYK2 not JAK1.

Modifications:
Participates in complexes:
In compartment: Membrane
  1. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL13@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
As Catalyser:
  1. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  2. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  3. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map