Protein CSF2 map

Identifiers
HUGO:CSF2

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:24669294
SCF2 (GM-CSF) is assosiated with M1 phenotype of macrophages
PMID:12928384
GM-CSF enhances monocyte APC function. GM-CSF increases surface class II MHC expression and decreases the relative level of the invariant chain-derived peptide, CLIP, bound to surface class II molecules. GM-CSF also increases expression of the costimulatory molecules CD86 and CD40.
Additional analyses of the class II pathway revealed that GM-CSF increases total protein and RNA levels of HLA-DR, DM, and DOalpha. Expression of class II transactivator (CIITA) types I and III, but not IV, transcripts increases in response to GM-CSF. Furthermore, GM-CSF increases the amount of CIITA associated with the DR promoter. Thus, our data argue that the proinflammatory role of GM-CSF is mediated in part through increased expression of key molecules involved in the class II MHC pathway via induction of CIITA.
PMID: 24030977
SCF2 (GM-CSF) promotes the immunosuppressive activity of glioma-infiltrating myeloid cells (MDSC) through upregulation of expression of interleukin-4 receptor-??.
PMID:22698406
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is necessary and sufficient to drive the development of Gr-1(+) CD11b(+) cells that suppressed antigen-specific T cells. In vivo, abrogation of tumor-derived GM-CSF inhibited the recruitment of Gr-1(+) CD11b(+) cells to the tumor microenvironment and blocked tumor development-a finding that was dependent on CD8(+) T cells.
PMID:20406969
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.

CSF2@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: default
  1. CSF2@default map
Participates in complexes:
In compartment: Membrane
  1. CSF2:​CSF2RA:​CSF2RB:​JAK2@Membrane map
Participates in reactions:
As Reactant or Product:
  1. CSF2@default map + CSF2RA:​CSF2RB@Membrane map + JAK2@Membrane map → map CSF2:​CSF2RA:​CSF2RB:​JAK2@Membrane map
  2. CSF2@default map → map Macrophage-mediated tumor cytotoxicity@Membrane map
  3. CSF2@default map → map Antibody-dependent cellular cytotoxicity@Membrane map
  4. CSF2@default map → map Migration into tumor@default map
As Catalyser:
  1. gTNF@Cytosol map → map rTNF@Cytosol map
  2. rIL12p35*@Cytosol map → map IL12p35*@Cytosol map
  3. NFKBIA|​pho@Cytosol map → map degraded
  4. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  5. NFKB1_p50*@Cytosol map → map NFKB1_p50*|​hm2@Cytosol map
  6. gVEGFA@Cytosol map → map rVEGFA@Cytosol map
  7. HIF1A@Cytosol map → map HIF1A@Cytosol map
  8. gVEGFR1*@Cytosol map → map rVEGFR1*@Cytosol map
  9. rIL23A@Cytosol map → map IL23A@Cytosol map
  10. gIRF5@Cytosol map → map rIRF5@Cytosol map
  11. RELA@Cytosol map + NFKB1_p50*@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map
  12. gIL4R@Cytosol map → map rIL4R@Cytosol map
  13. STAT5*@Cytosol map → map STAT5*|​pho@Cytosol map