Reaction heterodimer_association re317 map

JAK2@Cytosol map + JAK1@Cytosol map + IFNGR1:​IFNGR2@Membrane map + IFNG|​hm2@default map → IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map

Reaction regulators:
Inhibition
  1. SOCS1@Cytosol map





Identifiers

Maps_Modules

References
PMID:17525754, PMID:9202126
SOCS-1 decreases IFNG signaling via inhiviting the catalytic activity of JAKs.
PMID:12811837, PMID:10485906
,SOCS-1 overexpression resulted in a nearly complete loss of IFNG responsiveness in macrophages