Reaction heterodimer_association re133 map

IL13@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map

No reaction regulators




Identifiers

Maps_Modules

References
PMID:14610620, PMID:12223527
IL13 acts via IL4 receptor type 2, which contains two subunits IL4R and IL13RA1
PMID:14610620, PMID:12223527, PMID:20510870
JAK1 associated with IL4R and JAK2 or TYK associated with IL13RA1 participate in signal transduction; They phosphorylate the second,
third, or fourth tyrosine residues of the IL-4Ra cytoplasmic domain.
PMID:23124025
IL13 signaling aktivates JAK2 and TYK2 not JAK1.