Complex IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2 map
Complex composition:

  1. TYK2 map
  2. JAK1 map
  3. JAK2 map
  4. IL4 map
  5. IL13RA1 map
  6. IL4R map

IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane

Identifiers
NAME:IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2

Maps_Modules
MODULE:MACROPHAGE

References
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4R????and common gamma-chain (IL-2R??);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:12223527
Type II IL-4 receptors associates with Jak1,JAK2 and TYK2
PMID:23124025
IL4 binding induces Jak1 phosphorylation (but not Jak2, JAK3, or TYK2).

Modifications:
Participates in complexes:
In compartment: Membrane
  1. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL4@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
As Catalyser:
  1. gTIMP3@Cytosol map → map rTIMP3@Cytosol map