Protein STAT1 map

Identifiers
HUGO:STAT1

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
PMID: PMID:19833085
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.
PMID:17689680
STAT1 acetilation inhibits its activity in macrophages.
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:14607900
FNG inhibits IL10 signalind via STAT1.
STAT1 overexpression prevents STAT3 homodimerization.
PMID:12193701, PMID:11830590
CD40 expression is upregulated by STAT1 downstream of INFG
and NF-kB downstream of TNF.
PMID:12193701
INFG upregulates TNFR1 and PIPK1 expression, probably via JAK/STAT1 pathway
because this expression is inhibited in presense of SOCS1.
PMID:15814715, PMID:18272812, PMID:17016554
STAT1 is involeved in immunosupresive activity of M2 macrophages and MDSC, probably downstream of IFNG.

STAT1|​pho|​active@Cytosol

Identifiers

Maps_Modules

References

STAT1@Cytosol

Identifiers

Maps_Modules

References

STAT1|​ace@Cytosol

Identifiers

Maps_Modules

References

STAT1|​pho|​ace@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. STAT1@Cytosol map
  2. STAT1|​ace@Cytosol map
  3. STAT1|​pho|​ace@Cytosol map
  4. STAT1|​pho|​active@Cytosol map
Participates in complexes:
In compartment: Membrane
  1. STAT1|​pho:​TNFR1*@Membrane map
Participates in reactions:
As Reactant or Product:
  1. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  2. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  3. STAT1|​pho|​active@Cytosol map → map STAT1|​pho|​ace@Cytosol map
  4. STAT1|​pho|​ace@Cytosol map → map STAT1|​ace@Cytosol map
  5. STAT1|​ace@Cytosol map → map STAT1@Cytosol map
  6. STAT1|​pho|​ace@Cytosol map → map STAT1|​pho|​active@Cytosol map
  7. STAT1|​pho|​active@Cytosol map → map STAT1@Cytosol map
  8. STAT1|​pho|​active@Cytosol map + TNFR1*@Membrane map → map STAT1|​pho:​TNFR1*@Membrane map
As Catalyser:
  1. gALOX15@Cytosol map → map rALOX15@Cytosol map
  2. gMAOA@Cytosol map → map rMAOA@Cytosol map
  3. rCCL2@Cytosol map → map CCL2@Cytosol map
  4. gIRF1@Cytosol map → map rIRF1@Cytosol map
  5. STAT3|​pho|​active@Cytosol map → map STAT3|​pho|​hm2|​active@Cytosol map
  6. gCD40@Cytosol map → map rCD40@Cytosol map
  7. gTNFR1*@Cytosol map → map rTNFR1*@Cytosol map
  8. gRIPK1@Cytosol map → map rRIPK1@Cytosol map
  9. gNOS2@Cytosol map → map rNOS2@Cytosol map