Protein IL4 map

Identifiers
HUGO:IL4

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:12401408
IL4 is assosiated with M2 polarization of macrophages
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4R????and common gamma-chain (IL-2R??);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:12496409
Arg1 is up-regulated in MDSC by IL-4.
Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS), and that superoxide is required for Arg1-dependent suppression of T cell function.

Modifications:
In compartment: default
  1. IL4@default map
Participates in complexes:
In compartment: Membrane
  1. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@Membrane map
  2. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL4@default map + IL2RG:​IL4R@Membrane map + JAK3@Cytosol map + JAK2@Cytosol map + JAK1@Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@Membrane map
  2. IL4@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
As Catalyser:
  1. IRS2@Cytosol map → map IRS2|​pho@Cytosol map
  2. gTIMP3@Cytosol map → map rTIMP3@Cytosol map
  3. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  4. gHIF1A@Cytosol map → map rHIF1A@Cytosol map
  5. rHIF1A@Cytosol map → map HIF1A@Cytosol map
  6. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map
  7. gMAF@Cytosol map → map rMAF@Cytosol map
  8. gMYC@Cytosol map → map rMYC@Cytosol map
  9. LGALS3@Cytosol map → map LGALS3@default map