Protein TYK2 map

Identifiers
HUGO:TYK2

Maps_Modules

References
MODUULE:MACROPHAGE
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
PMID:14610620
TYK2 is a member of the Janus kinase family.
TYK2 associated with IL13RA1 participates in signal transduction.
PMID:???21115385, PMID:7543512
???The binding of IL-10 to its receptor activates two members of the Janus kinase family: Jak1 (associated with the IL-1OR1 and
Tyk2 (associated with the IL-10R2)
IL-10 treatment of monocytes results in the tyrosine phosphorylation of tyk2 and Jakl

TYK2@Cytosol

Identifiers

Maps_Modules

References

TYK2@Membrane

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. TYK2@Cytosol map
In compartment: Membrane
  1. TYK2@Membrane map
Participates in complexes:
In compartment: Membrane
  1. IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  2. IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  3. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
  4. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL13@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
  2. IL10:​IL10RA:​IL10RB@Membrane map + JAK1@Membrane map + TYK2@Membrane map → map IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  3. IL4@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
  4. IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map → map IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
As Catalyser:
  1. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  2. gTIMP3@Cytosol map → map rTIMP3@Cytosol map
  3. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  4. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map