Protein HIF1A map

Identifiers
HUGO:HIF1A

Maps_Modules
MODULE:MACROPHAGE
MODULE:RECRUITMENT_OF_IMMUNE_CELLS

References
PMID:24006507
HIF1A expression is assotiated with classical activation of macrophages
PMID:20427344
HIF1 expression is assotiated with classical activation of macrophages
HIF1A upregulates expression of: TNF, IL6, HIF1A downregulates expression of M2 markers CD206 and STAB1.
PMID_24006507
IL4 downregulates HIF1a translation.
PMID:21765015
CSF2 upregulates VEGF expression via HIF1a specific inhibition of PHD2 increases VEGF production
HIF1a induces MIF expression of macrophages after hypoxia.
IL4+IL13 inhibit MIF expression via inhibition of HIF1a expression.
PMID:16127144
HIF-1A and HIF-2A are up-regulated by human macrophages exposed to hypoxia??in vitro??and by TAMs in hypoxic/necrotic areas of human tumors.
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1??.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth

HIF1A@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. HIF1A@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rHIF1A@Cytosol map → map HIF1A@Cytosol map
    2. HIF1A@Cytosol map → map HIF1A@Cytosol map
    3. HIF1A@Cytosol map → map degraded
    As Catalyser:
    1. gARG1@Cytosol map → map rARG1@Cytosol map
    2. gMIF@Cytosol map → map rMIF@Cytosol map
    3. gVEGFA@Cytosol map → map rVEGFA@Cytosol map
    4. gNOS2@Cytosol map → map rNOS2@Cytosol map