Protein JAK1 map

Identifiers
HUGO:JAK1

Maps_Modules

References
MODULE:MACROPHAGE
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
PMID:???21115385
???JAK1 is a member of the Janus kinase family.
???The binding of IL-10 to its receptor activates two members of the Janus kinase family: Jak1 (associated with the IL-1OR1 and
Tyk2 (associated with the IL-10R2)
PMID: PMID:19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2

JAK1@Cytosol

Identifiers

Maps_Modules

References

JAK1@Membrane

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. JAK1@Cytosol map
In compartment: Membrane
  1. JAK1@Membrane map
Participates in complexes:
In compartment: Membrane
  1. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
  2. IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  3. IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  4. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@Membrane map
  5. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
  6. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL4@default map + IL2RG:​IL4R@Membrane map + JAK3@Cytosol map + JAK2@Cytosol map + JAK1@Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@Membrane map
  2. IL13@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
  3. IL10:​IL10RA:​IL10RB@Membrane map + JAK1@Membrane map + TYK2@Membrane map → map IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  4. IL4@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@Membrane map
  5. IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map → map IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  6. JAK2@Cytosol map + JAK1@Cytosol map + IFNGR1:​IFNGR2@Membrane map + IFNG|​hm2@default map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
As Catalyser:
  1. rMHC class II*@Cytosol map → map MHC class II*@Cytosol map
  2. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  3. IRS2@Cytosol map → map IRS2|​pho@Cytosol map
  4. gTIMP3@Cytosol map → map rTIMP3@Cytosol map
  5. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  6. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map
  7. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map