Reaction state_transition re284 map

STAT6@Cytosol map → STAT6|​pho|​active@Cytosol map

Reaction regulators:
Catalysis
  1. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@Membrane map
  2. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
  3. PIP3*@Cytosol map
  4. p110*:​p85*@Cytosol map
Inhibition
  1. SOCS1@Cytosol map





Identifiers

Maps_Modules

References
PMID:23124025
Tyk2 IS required for Stat6 (TYR641) activation in monocytes stimulated with IL-13.
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
IL-4, in contrast to IL-13, induced very low levels of phosphorylation of Stats 1 and 5 and a more robust phosphorylation of Stat3 and Stat6.
Jak1 is required for Stat6 (TYR641) activation in monocytes stimulated with IL-4
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:21469115
PI3K signaling is involved in STAT6 activation.