Protein IRS2 map

Identifiers
HUGO:IRS2

Maps_Modules
MODULE:MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+??mobilization signaling and assosiation of IRS2 and PLCG1
PMID:7890616
PCL (probably PCLG1) induces t hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+??release downstream of IL13.
PMID:19109239
IL4 induces he tyrosine phosphorylation of IRS-2 via Type I IL-4 Receptors.
Activated IRS2 interacts with Grb2 and activates downstrean PI3K signalin.

IRS2|​pho@Cytosol

Identifiers

Maps_Modules

References

IRS2@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. IRS2@Cytosol map
  2. IRS2|​pho@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. GRB2:​IRS2|​pho@Cytosol map
  2. IRS2|​pho:​PLCG1|​pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IRS2|​pho@Cytosol map + PLCG1|​pho@Cytosol map → map IRS2|​pho:​PLCG1|​pho@Cytosol map
  2. IRS2@Cytosol map → map IRS2|​pho@Cytosol map
  3. GRB2@Cytosol map + IRS2|​pho@Cytosol map → map GRB2:​IRS2|​pho@Cytosol map
As Catalyser:
  1. p85*@Cytosol map → map p85*@Cytosol map