Complex CSF2:CSF2RA:CSF2RB:JAK2 map
Complex composition:

  1. CSF2 map
  2. CSF2RB map
  3. CSF2RA map
  4. JAK2 map

CSF2:​CSF2RA:​CSF2RB:​JAK2@Membrane

Identifiers
NAME:CSF2:CSF2RA:CSF2RB

Maps_Modules

References
PMID:12393492
CSF2 acts via heterodimer receptor contains CSF2RA and SSF2RB subunits
PMID:20406969, PMID:24091328, PMID:11867689
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation, probably downstream of JAK2. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.

Modifications:
Participates in complexes:
In compartment: Membrane
  1. CSF2:​CSF2RA:​CSF2RB:​JAK2@Membrane map
Participates in reactions:
As Reactant or Product:
  1. CSF2@default map + CSF2RA:​CSF2RB@Membrane map + JAK2@Membrane map → map CSF2:​CSF2RA:​CSF2RB:​JAK2@Membrane map
As Catalyser:
  1. gTNF@Cytosol map → map rTNF@Cytosol map
  2. rIL12p35*@Cytosol map → map IL12p35*@Cytosol map
  3. NFKBIA|​pho@Cytosol map → map degraded
  4. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  5. NFKB1_p50*@Cytosol map → map NFKB1_p50*|​hm2@Cytosol map
  6. gVEGFA@Cytosol map → map rVEGFA@Cytosol map
  7. HIF1A@Cytosol map → map HIF1A@Cytosol map
  8. gVEGFR1*@Cytosol map → map rVEGFR1*@Cytosol map
  9. rIL23A@Cytosol map → map IL23A@Cytosol map
  10. RELA@Cytosol map + NFKB1_p50*@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map
  11. STAT5*@Cytosol map → map STAT5*|​pho@Cytosol map