Complex IFNG:IFNGR1:IFNGR2:JAK1:JAK2 map
Complex composition:

  1. IFNG map
  2. JAK2 map
  3. JAK1 map
  4. IFNGR2 map
  5. IFNGR1 map

IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane

Identifiers
NAME:IFNG:IFNGR1:IFNGR2:JAK1:JAK2

Maps_Modules
MODULE:MACROPHAGE

References
PMID:17683974
IFNG dimer binds to receptor contained two IFNGR1 and two IFNGR2 subunits.
PMID: 19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2.
Ligand engagement of the IFNG receptor leads to activation of receptor-associated Jak1 and Jak2 and phosphorylation of a receptor tyrosine residue
(Y440) that serves as a docking site for STAT1, which exists in a latent state in the cytoplasm.

Modifications:
Participates in complexes:
In compartment: Membrane
  1. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
Participates in reactions:
As Reactant or Product:
  1. JAK2@Cytosol map + JAK1@Cytosol map + IFNGR1:​IFNGR2@Membrane map + IFNG|​hm2@default map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
As Catalyser:
  1. rMHC class II*@Cytosol map → map MHC class II*@Cytosol map
  2. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map