Protein IL13 map

Identifiers
HUGO:IL13

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:12401408
IL13 is assosiated with M2 phenotype of macrophages
PMID:14610620, PMID:12223527
IL13 acts via IL4 receptor type 2, which contains two subunits IL4R and IL13RA1
PMID:14610620
Other receptor of IL13 is IL13RA2
PMID:18451175, PMID:14657224
IL13 signaling via IL13RA2 induces TGFB production in MDSC.

IL13@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: default
  1. IL13@default map
Participates in complexes:
In compartment: Membrane
  1. IL13:​IL13RA2@Membrane map
  2. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL13RA2@Cytosol map + IL13@default map → map IL13:​IL13RA2@Membrane map
  2. IL13@default map + IL13RA1:​IL4R@Membrane map + JAK1@Cytosol map + JAK2@Cytosol map + TYK2@Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@Membrane map
As Catalyser:
  1. FOSL2@Cytosol map → map FOSL2@Cytosol map
  2. JUN@Cytosol map → map JUN|​pho|​active@Cytosol map
  3. NFKBIA|​pho@Cytosol map → map degraded
  4. PLCG1@Cytosol map → map PLCG1|​pho@Cytosol map
  5. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  6. IRS2@Cytosol map → map IRS2|​pho@Cytosol map
  7. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  8. TGFB1@Cytosol map → map TGFB1@default map
  9. gHIF1A@Cytosol map → map rHIF1A@Cytosol map
  10. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map
  11. gSOCS1@Cytosol map → map rSOCS1@Cytosol map
  12. RELA@Cytosol map + NFKB1_p50*@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map
  13. LGALS3@Cytosol map → map LGALS3@default map
  14. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map