Reaction translation re172 map

rMHC class II*@Cytosol map → MHC class II*@Cytosol map

Reaction regulators:
Boolean_logic_gate_and
  1. CIITA@Cytosol map and HMGB1@default map
Catalysis
  1. CIITA@Cytosol map
  2. HMGB1@default map
  3. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
Inhibition
  1. IRF4@Cytosol map





Identifiers

Maps_Modules

References
PMID:16243976
INFG upregulates surface expression of MHC II.
IRF4 is a target of MIR125B1, inhibition of IRF4 by MIR125B1 resulted in increased surface expression of MHC II.
PMID:15644117
HMGB1 upregulates the expression of MHC class II molecules on the surface of macrophages.
PMID:12928384
CSF2 (GM-CSF) increases surface class II MHC and costimulatory molecule expression in primary human monocytes without evidence of differentiation.
PMID:8871614
IL13 induces MHC classe II expression via STAT6 pathway