Identifiers
HUGO:TNF

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION

References
PMID:1431106
TNF is ploinfammatory cytokine induced
tumoricidal activity of macrophages
PMID:10754326
Human TNF-alpha gene has binding sites for NF-kappa B. By transient transfection,
NF-kappa B p65 and p50 synergistically activated the TNF-alpha promoter.
Although both the kappa B1 and kappa B3 sites bound transcriptionally active NF-kappa B p50/p65 heterodimers, only the kappa
B1 site contributed to down-regulation by NF-kappa B p50 homodimers.
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
mRNA expression of several NF-??B target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC

Identifiers

Maps_Modules

References

1. gTNF@Cytosol

1. gTNF@Cytosol → rTNF@Cytosol