Protein IFNG map

Identifiers
HUGO:IFNG

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:12413632
IFNG is a major factor of M1 activation of macrophages.
PMID:6425450
Monoclonal antibody to IFNG inhibits macrophage tumoricidal activities.
PMID:11964313
INFG potentiates TLR signaling and NFkB activation downstream of TLR.
PMID:9864217
IFNG cooperates with TNF and TLR signaling in NF-kB activation.
PMID:19833085
IFNG achieves strong activation effects is by enhancing macrophage
responsiveness to other inflammatory stimuli, such as TLR ligands and TNF.
PMID:14607900, PMID:16713974
IFNG impairs IL-10 anti-inflammatory activity.
PMID:10485906
IFNG downregulates IL4 signaling pathway via SOCS1.
PMID:16713974
INFG signaling inhibits p38 activation
PMID:15814715, PMID:18272812, PMID:17016554
STAT1 is involeved in immunosupresive activity of M2 macrophages and MDSC, probably downstream of IFNG.
activation of MSCs is initiated in response to IFN-gamma, presumably produced in situ by antitumor T cells in the tumor microenvironment.
PMID: 16424049
The secretion of interleukin (IL)-10 and transforming growth factor-beta by Gr-1(+)CD115(+) MSCs and iNOS expression was induced and enhanced, respectively, on IFN-gamma stimulation.

IFNG@Cytosol

Identifiers

Maps_Modules

References

IFNG|​hm2@default

Identifiers

Maps_Modules

References

IFNG@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. IFNG@Cytosol map
In compartment: default
  1. IFNG@default map
  2. IFNG|​hm2@default map
Participates in complexes:
In compartment: Membrane
  1. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IFNG@default map → map IFNG|​hm2@default map
  2. JAK2@Cytosol map + JAK1@Cytosol map + IFNGR1:​IFNGR2@Membrane map + IFNG|​hm2@default map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
  3. IFNG|​hm2@default map → map Macrophage-mediated tumor cytotoxicity@Membrane map
  4. IFNG@Cytosol map → map IFNG@default map
  5. rINFG@Cytosol map → map IFNG@Cytosol map
As Catalyser:
  1. gTGFB1@Cytosol map → map rTGFB1@Cytosol map
  2. rMHC class II*@Cytosol map → map MHC class II*@Cytosol map
  3. gIL10@Cytosol map → map rIL10@Cytosol map
  4. rCD80@Cytosol map → map CD80@Membrane map
  5. gMIF@Cytosol map → map rMIF@Cytosol map
  6. gHIF2A*@Cytosol map → map rHIF2A*@Cytosol map
  7. gHIF1A@Cytosol map → map rHIF1A@Cytosol map
  8. gTLR2@Cytosol map → map rTLR2@Cytosol map
  9. rTLR2@Cytosol map → map TLR2@Membrane map
  10. gTLR4@Cytosol map → map rTLR4@Cytosol map
  11. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  12. gLY96@Cytosol map → map rLY96@Cytosol map
  13. gMYD88@Cytosol map → map rMYD88@Cytosol map
  14. gRELA@Cytosol map → map rRELA@Cytosol map
  15. ERK*@Cytosol map → map ERK*|​pho|​active@Cytosol map
  16. JNK*@Cytosol map → map JNK*|​pho|​active@Cytosol map
  17. PIP2*@Cytosol map → map PIP3*@Cytosol map
  18. gFOS@Cytosol map → map rFOS@Cytosol map
  19. rJUN@Cytosol map → map JUN@Cytosol map
  20. STAT1|​pho|​active@Cytosol map + TNFR1*@Membrane map → map STAT1|​pho:​TNFR1*@Membrane map
  21. rCD18@Cytosol map → map CD18*@Cytosol map
  22. rICAM1@Cytosol map → map ICAM1@Membrane map
  23. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map