Identifiers
breast cancer 1, early onset
HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / G1_S_CHECKPOINT 
 Cell Cycle DNA Repair   / S_PHASE_CHECKPOINT 
 Cell Cycle DNA Repair   / G2_M_CHECKPOINT 
 Cell Cycle DNA Repair   / HR 
 Cell Cycle DNA Repair   / FANCONI 
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 

References
For S-phase checkpoint
PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331

References
ce_re523( Cell Cycle DNA Repair  ):
HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents
PMID:22869732

References
ce_re33:( Cell Cycle DNA Repair  ) PMID:15485915
ce_re34:( Cell Cycle DNA Repair  ) PMID:19788416
ce_re48( Cell Cycle DNA Repair  ):
BRCA1 stabilises p53 and causes activation of p53-dependent DNA-repair genes and activation of checkpoint, but no apoptoss:
PMID:12024039 , PMID:12496474
ce_re118( Cell Cycle DNA Repair  ):
BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint
PMID:16818604
PMID:19357644
ce_re121( Cell Cycle DNA Repair  ):
The shift from C_NHEJ to HR is regulated by the CtIP and BRCA1. CDK1-dependent phosphorylation of CtIP regulates the shift: PMID:19357644
PMID:15485915
ce_re166( Cell Cycle DNA Repair  ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
ce_re204:( Cell Cycle DNA Repair  ) PMID:15242590
ce_re226( Cell Cycle DNA Repair  ):
BRCA1 up-regulates transcription of GADD45 in p53 independed manner:
PMID:10367887, PMID:10962562
PMID:19004803, PMID:12496474
p53 enhances transcription of GADD45:
PMID:9892649, PMID:10779360
p53 regulated global genomic NER at the level of DNA damage recognition involving GADD45, XPC, DDB2:
PMID:12771027, PMID:9346961
ce_re228( Cell Cycle DNA Repair  ):
BRCA1 enhances transcription of DDB2 in p53 independent manner
PMID:19004803, PMID:12496474, PMID:12170778
p53 enhances transcription of DDB2:
ce_re231( Cell Cycle DNA Repair  ):
BRCA1 upregulates transcription of XPC in p53 independed manner:
p53 enhances transcription of XPC:
ce_re344:( Cell Cycle DNA Repair  ) CHECKPOINT is p53_dependent_G1S_checkpoint

References
ce_re523( Cell Cycle DNA Repair  ):
HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents
PMID:22869732

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 

References
rc_re1070:( Regulated Cell Death  ) PMID:16326698

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 

References
rc_re1508( Regulated Cell Death  ):
influenceDelete: re to reactants
PMID:19342239
review
genetic arguments for the components of this complex being recruited all together
rc_re1502( Regulated Cell Death  ):
influenceDelete: re to products
PMID:18087291

1. BRCA1@Cytosol

1. BRCA1@Mitochondrial Matrix

1. BRCA1@Nucleus
2. BRCA1|​ubi@Nucleus
3. BRCA1|​S308_pho@Nucleus
4. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus

1. BRCA1@Site of DNA damage

1. ACACA|​S79_pho:​BRCA1@Cytosol

1. BARD1:​BRCA1@Nucleus
2. AURKA:​BRCA1|​S308_pho@Nucleus
3. BRCA1:​SMC1*|​S957_pho@Nucleus
4. BRCA1:​SMC3|​S1083_pho@Nucleus
5. BRCA1:​FANCJ*|​S990_pho@Nucleus
6. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@Nucleus
7. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@Nucleus
8. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*@Nucleus
9. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*@Nucleus
10. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@Nucleus
11. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus
12. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus
13. BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@Nucleus

1. BARD1:​BRCA1:​BRCC3:​FAM175A:​UIMC1@Site of DNA damage

1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@Nucleus + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@Nucleus → BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@Nucleus
2. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@Nucleus + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus → BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@Nucleus
3. BARD1@Nucleus + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus → BARD1:​BRCA1@Nucleus
4. RAD51:​XRCC2:​XRCC3@Nucleus + BARD1:​BRCA1@Nucleus + RAD52@Nucleus + BRCA2:​DSS1*@Nucleus + FANCN*@Nucleus + FANCD2|​K561_ubi|​pho@Nucleus + BRIT1*@Nucleus + SFPQ@Nucleus → BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@Nucleus
5. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@Nucleus + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus + BRCA2@Nucleus + NBS1*|​S343_pho@Nucleus + RAD51@Nucleus + PCNA@Nucleus + H2AFX|​S139_pho|​ubi@Nucleus + TIP60*@Nucleus → BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus
6. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus + BRCA2@Nucleus + FANCJ*@Nucleus + RPA1:​RPA2:​RPA3@Nucleus + FANCN*@Nucleus + FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@Nucleus → BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*@Nucleus
7. FANCJ*|​S990_pho@Nucleus + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus → BRCA1:​FANCJ*|​S990_pho@Nucleus
8. rBRCA1@Nucleus → BRCA1@Nucleus
9. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus → BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus
10. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*@Nucleus → BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*@Nucleus
11. BRCA1@Nucleus → BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus
12. E2F1:​RB1@Nucleus + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus → BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@Nucleus
13. BRCA1@Nucleus → BRCA1|​S308_pho@Nucleus
14. BRCA1|​S308_pho@Nucleus + AURKA@Nucleus → AURKA:​BRCA1|​S308_pho@Nucleus
15. BRCA1@Nucleus + SMC1*|​S957_pho|​S966_pho@Nucleus → BRCA1:​SMC1*|​S957_pho@Nucleus
16. SMC3|​S1083_pho@Nucleus + BRCA1@Nucleus → BRCA1:​SMC3|​S1083_pho@Nucleus
17. BRCA1@Nucleus → BRCA1|​ubi@Nucleus
18. BRCA1|​ubi@Nucleus → degraded
19. rheavy strand transcript*@Mitochondrial Matrix → rMT-TT@Mitochondrial Matrix + rMT-ND5@Mitochondrial Matrix + BARD1@Mitochondrial Matrix + PYCARD@Mitochondrial Matrix + BAX@Mitochondrial Matrix + rMT-ND4@Mitochondrial Matrix + rMT-ND4L@Mitochondrial Matrix + BRCA1@Mitochondrial Matrix + rMT-ND3@Mitochondrial Matrix + BIRC5@Mitochondrial Matrix + rMT-CO3@Mitochondrial Matrix + rMT-ATP6@Mitochondrial Matrix + rMT-ATP8@Mitochondrial Matrix + rMT-TK@Mitochondrial Matrix + rMT-CO2@Mitochondrial Matrix + rMT-TD@Mitochondrial Matrix + rMT-CO1@Mitochondrial Matrix + rMT-TW@Mitochondrial Matrix + rMT-ND2@Mitochondrial Matrix + rMT-TM@Mitochondrial Matrix + rMT-TI@Mitochondrial Matrix + rMT-ND1@Mitochondrial Matrix + rMT-TL1@Mitochondrial Matrix + rMT-RNR2@Mitochondrial Matrix + rMT-TV@Mitochondrial Matrix + rMT-RNR1@Mitochondrial Matrix + rMT-TF@Mitochondrial Matrix + rMT-CYB@Mitochondrial Matrix
20. BRCA1@Cytosol + ACACA|​S1263_pho@Cytosol → ACACA|​S79_pho:​BRCA1@Cytosol
21. BRCA1@Site of DNA damage → BRCA1@Nucleus
22. BRCA1@Nucleus + FAM175A@Site of DNA damage + UIMC1@Site of DNA damage + BRCC3@Site of DNA damage + BARD1@Site of DNA damage → BARD1:​BRCA1:​BRCC3:​FAM175A:​UIMC1@Site of DNA damage
23. BARD1:​BRCA1:​BRCC3:​FAM175A:​UIMC1@Site of DNA damage → BRCA1@Site of DNA damage + UIMC1@Site of DNA damage + FAM175A@Site of DNA damage + BRCC3@Site of DNA damage + BARD1@Site of DNA damage

1. gHR_DNA_st1*@Nucleus → gHR_DNA_st2*@Nucleus
2. G1 phase@Nucleus → S phase@Nucleus
3. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@Nucleus → CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@Nucleus
4. G2 phase@Nucleus → M phase@Nucleus
5. gHR_DNA_st2*@Nucleus → gHR_DNA_st3*@Nucleus
6. gHR_DNA_st3*@Nucleus → gHR_DNA_st4*@Nucleus
7. gFanconi_DNA_st4*@Nucleus → gFanconi_DNA_st5*@Nucleus
8. gFanconi_DNA_st4*@Nucleus → gHR_DNA_st2*@Nucleus
9. gGADD45*@Nucleus → rGADD45*@Nucleus
10. gDDB2@Nucleus → rDDB2@Nucleus
11. gXPC@Nucleus → rXPC@Nucleus
12. CHEK1@Nucleus → CHEK1|​pho|​active@Nucleus
13. p53*@Nucleus → p53*|​pho|​ace|​active@Nucleus
14. gCIP/KIP*@Nucleus → rCIP/KIP*@Nucleus
15. gMAD2*@Nucleus → rMAD2*@Nucleus
16. gBUB1@Nucleus → rBUB1@Nucleus
17. No DNA replicarion@Nucleus → DNA replicarion@Nucleus
18. p53*@Nucleus → degraded
19. gC_NHEJ_DNA_st1*@Nucleus → gC_NHEJ_DNA_st2*@Nucleus
20. DNA~damage@Nucleus + gDNA2@Nucleus → DNA~integrity@Nucleus