Identifiers
baculoviral IAP repeat-containing 5, Surverin
HUGO:BIRC5, HGNC:593, ENTREZ:332, UNIPROT:Q9P2W8
baculoviral IAP repeat containing 5
HUGO:BIRC5 HGNC:593 ENTREZ:332 UNIPROT:O15392

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 

References
Component of the chromosomal passenger complex (CPC)
PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674
synonym:survivin

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 

References
rc_re669:( Regulated Cell Death  ) PMID:11069302
rc_re718:( Regulated Cell Death  ) PMID:14614132

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 

References
rc_re669:( Regulated Cell Death  ) PMID:11069302
rc_re668( Regulated Cell Death  ):
PMID:12773388
in vitro survivin_BIRC5 alone does not suppress CASP3/7/9 activities
in HepG2, interaction by coIP of endogenous proteins
in HEK293 or in vitro, preferential binding to T34 phosphorylated BIRC5, as determined through the use of unphosphorylatable or phosphomimetic mutants
in Hela expression of a dominant negative CDC2 decreases interaction
rc_re737( Regulated Cell Death  ):
PMID:12660240
in Hela, upon taxol treatment, interaction detected by GST pull-down, BIRC5 antagonizes DIABLO pro-apoptotic effect

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 

1. BIRC5@Cytosol
2. BIRC5|​T34_pho@Cytosol

1. BIRC5@Mitochondrial Matrix

1. BIRC5@Nucleus

1. BIRC5|​T34_pho:​HBXIP@Cytosol
2. BIRC5|​T34_pho:​DIABLO@Cytosol

1. AURKB|​T232_pho:​BIRC5:​Borealin*|​pho:​INCENP|​pho@Nucleus

1. Borealin*|​pho@Nucleus + AURKB|​T232_pho@Nucleus + INCENP|​pho@Nucleus + BIRC5@Nucleus → AURKB|​T232_pho:​BIRC5:​Borealin*|​pho:​INCENP|​pho@Nucleus
2. rheavy strand transcript*@Mitochondrial Matrix → rMT-TT@Mitochondrial Matrix + rMT-ND5@Mitochondrial Matrix + BARD1@Mitochondrial Matrix + PYCARD@Mitochondrial Matrix + BAX@Mitochondrial Matrix + rMT-ND4@Mitochondrial Matrix + rMT-ND4L@Mitochondrial Matrix + BRCA1@Mitochondrial Matrix + rMT-ND3@Mitochondrial Matrix + BIRC5@Mitochondrial Matrix + rMT-CO3@Mitochondrial Matrix + rMT-ATP6@Mitochondrial Matrix + rMT-ATP8@Mitochondrial Matrix + rMT-TK@Mitochondrial Matrix + rMT-CO2@Mitochondrial Matrix + rMT-TD@Mitochondrial Matrix + rMT-CO1@Mitochondrial Matrix + rMT-TW@Mitochondrial Matrix + rMT-ND2@Mitochondrial Matrix + rMT-TM@Mitochondrial Matrix + rMT-TI@Mitochondrial Matrix + rMT-ND1@Mitochondrial Matrix + rMT-TL1@Mitochondrial Matrix + rMT-RNR2@Mitochondrial Matrix + rMT-TV@Mitochondrial Matrix + rMT-RNR1@Mitochondrial Matrix + rMT-TF@Mitochondrial Matrix + rMT-CYB@Mitochondrial Matrix
3. rBIRC5@Nucleus → BIRC5@Cytosol
4. HBXIP@Cytosol + BIRC5|​T34_pho@Cytosol → BIRC5|​T34_pho:​HBXIP@Cytosol
5. BIRC5@Cytosol → BIRC5|​T34_pho@Cytosol
6. BIRC5@Cytosol → degraded
7. BIRC5|​T34_pho@Cytosol + DIABLO@Cytosol → BIRC5|​T34_pho:​DIABLO@Cytosol

1. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus + MAD2*@Nucleus + BUBR1*@Nucleus + BUB3@Nucleus + MAD1*|​pho@Nucleus + BUB1|​pho@Nucleus → APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​BUB1|​pho:​BUB3:​BUBR1*:​CDC20:​MAD1*|​pho:​MAD2*@Nucleus
2. Caspase9*@Cytosol → cleaved~Caspase9*@Cytosol