Identifiers
Fanconi anemia, complementation group D2
HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / G2_M_CHECKPOINT
Cell Cycle DNA Repair / FANCONI
References
PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763
References
ce_re198( Cell Cycle DNA Repair ):
ATM phosphotylates FANCD2 for S-phase checkpoint arrest in responce to IR.
PMID:12086603
ce_re115( Cell Cycle DNA Repair ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
ce_re119( Cell Cycle DNA Repair ):
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
References
ce_re158( Cell Cycle DNA Repair ):
S phase checkpoint controls and induces FANCD2 monoubiquitusation to start Fanconi and HR
PMID:12239151
ce_re146( Cell Cycle DNA Repair ):
Link between Fanconi and HR:
PMID:15650050, PMID:19686080
ce_re162( Cell Cycle DNA Repair ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404
ce_re206( Cell Cycle DNA Repair ):
Phosphorylation of NBS1 bt ATR in responce to crosslink-activation of S phase checkpoint
PMID:15136767
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop cell cycle propagation:
PMID:14988723
References
ce_re187( Cell Cycle DNA Repair ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
ce_re158( Cell Cycle DNA Repair ):
S phase checkpoint controls and induces FANCD2 monoubiquitusation to start Fanconi and HR
PMID:12239151
References
ce_re187( Cell Cycle DNA Repair ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
ce_re198( Cell Cycle DNA Repair ):
ATM phosphotylates FANCD2 for S-phase checkpoint arrest in responce to IR.
PMID:12086603
+ BARD1:BRCA1@Nucleus + RAD52@Nucleus + BRCA2:DSS1*@Nucleus + FANCN*@Nucleus + FANCD2|K561_ubi|pho@Nucleus + BRIT1*@Nucleus + SFPQ@Nucleus → BARD1:BRCA1:BRCA2:BRIT1*:DSS1*:FANCD2|K561_ubi|pho:FANCN*:RAD51:RAD52:SFPQ:XRCC2:XRCC3@Nucleus
→ FANCD2|K561_ubi|pho@Nucleus
+ FANCI|K523_ubi|pho@Nucleus → FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho@Nucleus
+ BRCA1|S988_pho|S1387_pho|S1423_pho|S1497_pho|S1524_pho|active@Nucleus + BRCA2@Nucleus + NBS1*|S343_pho@Nucleus + RAD51@Nucleus + PCNA@Nucleus + H2AFX|S139_pho|ubi@Nucleus + TIP60*@Nucleus → BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
+ BRCA2@Nucleus + FANCJ*@Nucleus + RPA1:RPA2:RPA3@Nucleus + FANCN*@Nucleus + FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho@Nucleus → BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:FANCJ*:FANCN*@Nucleus
→ FANCD2|pho@Nucleus
→ FANCD2|pho@Nucleus
→ FANCD2|S222_pho@Nucleus
+ MRE11*:NBS1*|S343_pho:RAD50@Nucleus + ATR|pho|active@Nucleus → ATR|pho:FANCD2|K561_ubi|pho:MRE11*:NBS1*|S343_pho:RAD50@Nucleus
+ POLN@Nucleus → FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:POLN@Nucleus
→ BRCA1:BRCA2:FANCD2|pho:FANCI|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
→ BRCA1:BRCA2:FANCD2|pho:FANCI|pho:FANCJ*:FANCN*@Nucleus
→ S phase@Nucleus
→ G2 phase@Nucleus
→ M phase@Nucleus
→ gHR_DNA_st3*@Nucleus
→ gHR_DNA_st4*@Nucleus
→ gFanconi_DNA_st4*@Nucleus
→ gFanconi_DNA_st5*@Nucleus
→ gHR_DNA_st2*@Nucleus