Gene C_NHEJ_DNA_st1* map

Identifiers
C_NHEJ:DNA:st1
DNA with double strand break
Node_Type:Generic

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / C_NHEJ  map

References
PMID:22258607, PMID:22918414, PMID:20691907, PMID:23897299, PMID:23892398, PMID:23760025,
PMID:24050180
Double strand break triggers MRN complex association:first step in DNA damage recognition and initiation of G2/M checkpoint
PMID:17303408
C_NHEJ in dividing and non-dividing cells
PMID:23684800

gC_NHEJ_DNA_st1*@Nucleus

References
ce_re215( Cell Cycle DNA Repair  map ):
If the cell is in G1 phase, the double strand break will be repeated by C_NHEJ, because there is no homologous template from sister chromatide. If the cell is in S/G2 phase, HR will take place.
PMID:19490890
ce_re513( Cell Cycle DNA Repair  map ):
http://dnatraffic.ibb.waw.pl/classification/dna_damages
PMID:22258607, PMID:19267553, PMID:18256616
For C_NHEJ activation by IR
PMID:20691907, PMID:23012265, PMID:21785230
For C_NHEJ activation by UV
PMID:17293412, PMID:15367581
Topoisomerate inhibitors bloch double strand DNA repair by HR, C_NHEJ and Fanconi pathways
PMID:23259582
For HR
PMID:22123462, PMID:20693240
For Fanconi
PMID:21414716, PMID:23157317
For activation by Dbait
PMID:22068457, PMID:22815765, PMID:22042585, PMID:19621083
ce_re601:( Cell Cycle DNA Repair  map ) reactionType:is.a
ce_re36( Cell Cycle DNA Repair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
ce_re80( Cell Cycle DNA Repair  map ):
The complex MRN:BRCA1:phos-Ub-CtIP is central in the shift toward HR, because it activates resection for HR and blocks Ku70/80 of C_NHEJ:
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
ce_re91( Cell Cycle DNA Repair  map ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.
ce_re199( Cell Cycle DNA Repair  map ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
ce_re260( Cell Cycle DNA Repair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation

Modifications:
In compartment: Nucleus
  1. gC_NHEJ_DNA_st1*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gHR_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st1*@Nucleus map
    2. gDeaminated_alkylated_mismatched_base*@Nucleus map → map gC_NHEJ_DNA_st1*@Nucleus map
    3. gC_NHEJ_DNA_st1*@Nucleus map → map gDamaged_DNA*@Nucleus map
    4. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map → map gC_NHEJ_DNA_st1*@Nucleus map
    5. gIntact_DNA*@Nucleus map → map gC_NHEJ_DNA_st1*@Nucleus map
    6. gDouble_strand_breaks_DSB*@Nucleus map → map gC_NHEJ_DNA_st1*@Nucleus map
    7. gC_NHEJ_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st2*@Nucleus map
    As Catalyser:
    1. HCLK2*@Nucleus map + FAAP24*@Nucleus map + FANCM@Nucleus map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@Nucleus map
    2. ATR|​pho|​active@Nucleus map + ATRIP@Nucleus map → map ATRIP:​ATR|​pho@Nucleus map
    3. ATM@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus map
    4. PPP5C:​RAD17@Nucleus map → map PPP5C@Nucleus map + RAD17@Nucleus map
    5. PARP2|​unk|​pho@Nucleus map + PARP1|​PolyADPribose_unk|​pho@Nucleus map → map PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@Nucleus map
    6. PARP3@Nucleus map + PARP1|​PolyADPribose_unk|​pho@Nucleus map → map PARP1|​PolyADPribose_unk|​pho:​PARP3@Nucleus map
    7. MRE11*@Nucleus map + RAD50@Nucleus map + NBS1*|​S343_pho@Nucleus map → map MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map