Protein PYCARD map

Identifiers
PYD and CARD domain containing
HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3
synonyms:ASC

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / PYROPTOSIS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:26885855
PMID:27048821
PMID:27066895
PMID:27984721
Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms.
 MACROPHAGE  map
 MDSC  map
 DENDRITIC_CELL  map
CASCADE:P2RX7
CASCADE:TLR2_4
PMID:19104081
Inflammasome is needfull for processing and release of IL-1beta in monocytes downstream of TLR2 or TLR4 signaling.
It contains CASP1, Pycard, NLRP3 (NALP3)

PYCARD@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

PYCARD@Mitochondrial Matrix

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

Modifications:
In compartment: Cytosol
  1. PYCARD@Cytosol map
In compartment: Mitochondrial Matrix
  1. PYCARD@Mitochondrial Matrix map
Participates in complexes:
In compartment: Cytosol
  1. AIM2:​PYCARD@Cytosol map
  2. NLRC4:​PYCARD@Cytosol map
  3. NLRP3:​PYCARD@Cytosol map
  4. PYCARD:​Pyrin*@Cytosol map
  5. Caspase1*:​PYCARD@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map
  2. (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Inflammasome platforms
  1. AIM2:​PYCARD@Inflammasome platforms map
  2. NLRP3:​PYCARD@Inflammasome platforms map
  3. PYCARD:​Pyrin*@Inflammasome platforms map
  4. Caspase1*:​PYCARD@Inflammasome platforms map
  5. NLRC4|​pho:​PYCARD@Inflammasome platforms map
Participates in reactions:
As Reactant or Product:
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. rheavy strand transcript*@Mitochondrial Matrix map → map rMT-TT@Mitochondrial Matrix map + rMT-ND5@Mitochondrial Matrix map + BARD1@Mitochondrial Matrix map + PYCARD@Mitochondrial Matrix map + BAX@Mitochondrial Matrix map + rMT-ND4@Mitochondrial Matrix map + rMT-ND4L@Mitochondrial Matrix map + BRCA1@Mitochondrial Matrix map + rMT-ND3@Mitochondrial Matrix map + BIRC5@Mitochondrial Matrix map + rMT-CO3@Mitochondrial Matrix map + rMT-ATP6@Mitochondrial Matrix map + rMT-ATP8@Mitochondrial Matrix map + rMT-TK@Mitochondrial Matrix map + rMT-CO2@Mitochondrial Matrix map + rMT-TD@Mitochondrial Matrix map + rMT-CO1@Mitochondrial Matrix map + rMT-TW@Mitochondrial Matrix map + rMT-ND2@Mitochondrial Matrix map + rMT-TM@Mitochondrial Matrix map + rMT-TI@Mitochondrial Matrix map + rMT-ND1@Mitochondrial Matrix map + rMT-TL1@Mitochondrial Matrix map + rMT-RNR2@Mitochondrial Matrix map + rMT-TV@Mitochondrial Matrix map + rMT-RNR1@Mitochondrial Matrix map + rMT-TF@Mitochondrial Matrix map + rMT-CYB@Mitochondrial Matrix map
  3. rPYCARD@Nucleus map → map PYCARD@Cytosol map
  4. Caspase1*@Cytosol map + PYCARD@Cytosol map → map Caspase1*:​PYCARD@Cytosol map
  5. Pyrin*@Cytosol map + PYCARD:​Pyrin*@Cytosol map → map PYCARD:​Pyrin*@Inflammasome platforms map
  6. Pyrin*@Cytosol map + PYCARD@Cytosol map → map PYCARD:​Pyrin*@Cytosol map
  7. Caspase1*:​PYCARD@Cytosol map → map Caspase1*:​PYCARD@Inflammasome platforms map
  8. AIM2@Cytosol map + PYCARD@Cytosol map → map AIM2:​PYCARD@Cytosol map
  9. NLRC4@Cytosol map + PYCARD@Cytosol map → map NLRC4:​PYCARD@Cytosol map
  10. NLRP3@Cytosol map + PYCARD@Cytosol map → map NLRP3:​PYCARD@Cytosol map
  11. AIM2@Cytosol map + AIM2:​PYCARD@Cytosol map → map AIM2:​PYCARD@Inflammasome platforms map
  12. NLRC4|​pho@Cytosol map + NLRC4:​PYCARD@Cytosol map → map NLRC4|​pho:​PYCARD@Inflammasome platforms map
  13. NLRP3@Cytosol map + NLRP3:​PYCARD@Cytosol map → map NLRP3:​PYCARD@Inflammasome platforms map
As Catalyser:
  1. IL1B@INNATE_IMMUNE_CELL_Cytosol map → map trILB1@INNATE_IMMUNE_CELL_Cytosol map
  2. Caspase1*@Inflammasome platforms map → map cleaved~Caspase1*@Inflammasome platforms map
  3. Caspase1*:​PYCARD@Cytosol map → map Caspase1*:​PYCARD@Inflammasome platforms map
  4. BAX@Cytosol map → map BAX|​S163_unk|​T167_unk@Mitochondrial inner membrane map