Protein FANCJ* map

Identifiers
BRCA1 interacting protein C-terminal helicase 1, BACH1, FANCJ
HUGO:BRIP1, HGNC:20473, ENTREZ:83990, UNIPROT:Q9BX63

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / HR  map
 Cell Cycle DNA Repair  map  / TLS  map
 Cell Cycle DNA Repair  map  / FANCONI  map

References
PMID:19686080, PMID:19622404, PMID:18931676
Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism
PMID:20173781

FANCJ*|​S990_pho@Nucleus

References
ce_re204:( Cell Cycle DNA Repair  map ) PMID:15242590

FANCJ*@Nucleus

References
ce_re162( Cell Cycle DNA Repair  map ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404
ce_re250( Cell Cycle DNA Repair  map ):
Link between MMR and Fanconi:
PMID:17581638

Modifications:
In compartment: Nucleus
  1. FANCJ*@Nucleus map
  2. FANCJ*|​S990_pho@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. BRCA1:​FANCJ*|​S990_pho@Nucleus map
  2. FANCJ*:​MLH1:​PMS2@Nucleus map
  3. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*@Nucleus map
  4. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus map + BRCA2@Nucleus map + FANCJ*@Nucleus map + RPA1:​RPA2:​RPA3@Nucleus map + FANCN*@Nucleus map + FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@Nucleus map → map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*@Nucleus map
  2. FANCJ*|​S990_pho@Nucleus map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus map → map BRCA1:​FANCJ*|​S990_pho@Nucleus map
  3. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*@Nucleus map → map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*@Nucleus map
  4. FANCJ*@Nucleus map + MLH1:​PMS2@Nucleus map → map FANCJ*:​MLH1:​PMS2@Nucleus map
  5. FANCJ*@Nucleus map → map FANCJ*|​S990_pho@Nucleus map
As Catalyser:
  1. G2 phase@Nucleus map → map M phase@Nucleus map
  2. gHR_DNA_st2*@Nucleus map → map gHR_DNA_st3*@Nucleus map
  3. gHR_DNA_st3*@Nucleus map → map gHR_DNA_st4*@Nucleus map
  4. gFanconi_DNA_st3*@Nucleus map → map gFanconi_DNA_st4*@Nucleus map
  5. gFanconi_DNA_st4*@Nucleus map → map gFanconi_DNA_st5*@Nucleus map
  6. gFanconi_DNA_st4*@Nucleus map → map gHR_DNA_st2*@Nucleus map