Identifiers
nibrin
HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / S_PHASE_CHECKPOINT 
 Cell Cycle DNA Repair   / G2_M_CHECKPOINT 
 Cell Cycle DNA Repair   / HR 
 Cell Cycle DNA Repair   / A_NHEJ 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 

References
PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763
For S-phase checkpoint
PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550
synonym:NBS1

References
ce_re205( Cell Cycle DNA Repair  ):
Phosphorylation of NBS1 by ATR in response to crosslink-activation of S phase checkpoint
PMID:15136767, PMID:14988723

References
ce_re205( Cell Cycle DNA Repair  ):
Phosphorylation of NBS1 by ATR in response to crosslink-activation of S phase checkpoint
PMID:15136767, PMID:14988723
ce_re91( Cell Cycle DNA Repair  ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.
ce_re166( Cell Cycle DNA Repair  ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
ce_re187( Cell Cycle DNA Repair  ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 

References
rc_re1477( Regulated Cell Death  ):
influenceDelete: re to reactants
PMID:18813293
review
through RAD50
rc_re1478( Regulated Cell Death  ):
influenceDelete: re to products
PMID:18087291
review, more specifically retention of NBN
PMID:18001824
NBN interacts even with MDC1 mutated on its 3 phosphoacceptor sites

1. NBS1*@Nucleus
2. NBS1*|​S343_pho@Nucleus

1. NBS1*@Site of DNA damage

1. MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus
2. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus
3. ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus
4. ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus
5. ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus
6. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@Nucleus
7. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus
8. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus

1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@Nucleus + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@Nucleus → BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@Nucleus
2. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus + CTIP*|​emp@Nucleus + WRN@Nucleus → ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus
3. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@Nucleus + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus + BRCA2@Nucleus + NBS1*|​S343_pho@Nucleus + RAD51@Nucleus + PCNA@Nucleus + H2AFX|​S139_pho|​ubi@Nucleus + TIP60*@Nucleus → BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus
4. NBS1*@Nucleus → NBS1*|​S343_pho@Nucleus
5. FANCD2|​K561_ubi|​pho@Nucleus + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus + ATR|​pho|​active@Nucleus → ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus
6. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus → BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus
7. MRE11*@Nucleus + RAD50@Nucleus + NBS1*|​S343_pho@Nucleus → MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus
8. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus + H2AFX|​S139_pho|​ubi:​MDC1|​pho@Nucleus → ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus
9. ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus → ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus
10. rc_s4501 → RAD50@Site of DNA damage + MRE11*@Site of DNA damage + NBS1*@Site of DNA damage
11. NBS1*@Site of DNA damage → NBS1*@Nucleus
12. NBS1*@Nucleus + MRE11*@Nucleus + RAD50@Nucleus → rc_s4501

1. gA_NHEJ_DNA_st1*@Nucleus → gA_NHEJ_DNA_st2*@Nucleus
2. gHR_DNA_st1*@Nucleus → gHR_DNA_st2*@Nucleus
3. G1 phase@Nucleus → S phase@Nucleus
4. S phase@Nucleus → G2 phase@Nucleus
5. G2 phase@Nucleus → M phase@Nucleus
6. gHR_DNA_st2*@Nucleus → gHR_DNA_st3*@Nucleus
7. gFanconi_DNA_st2*@Nucleus → gFanconi_DNA_st3*@Nucleus
8. gFanconi_DNA_st3*@Nucleus → gFanconi_DNA_st4*@Nucleus
9. gFanconi_DNA_st4*@Nucleus → gHR_DNA_st2*@Nucleus
10. FANCD2@Nucleus → FANCD2|​pho@Nucleus
11. gSSA_DNA_st1*@Nucleus → gSSA_DNA_st2*@Nucleus
12. ATM@Nucleus → ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus
13. CHEK2@Nucleus → CHEK2|​pho|​active@Nucleus
14. Ku70*@Nucleus + Ku80*@Nucleus → Ku70*:​Ku80*@Nucleus
15. gC_NHEJ_DNA_st1*@Nucleus → gC_NHEJ_DNA_st2*@Nucleus
16. DNA-PK*@Nucleus → DNA-PK*|​pho@Nucleus
17. H2AFX@Nucleus → H2AFX|​S139_pho@Nucleus