BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*

Complex BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*

Complex composition:

BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:FANCJ*:FANCN*@Nucleus

Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / HR
Cell Cycle DNA Repair / FANCONI

BRCA1:BRCA2:FANCD2|pho:FANCI|pho:FANCJ*:FANCN*@Nucleus

Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / HR
Cell Cycle DNA Repair / FANCONI

References
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
ce_re249( Cell Cycle DNA Repair ):
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process:
ce_re139( Cell Cycle DNA Repair ):
PMID:19686080
POLH participates in the D-loop formation in HR:
PMID:16337602, PMID:16337601
Complex PolN:HEL308 participates in HR and in Fanconi PMID:19995904
ce_re163( Cell Cycle DNA Repair ):
POLH activates D-loop extention
PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
Presence of FA core complex is essential for thePolZ/Rev1 activity:
PMID:18448394
PoLQ/HEL308 in Fancon:
PMID:18472307
ce_re165( Cell Cycle DNA Repair ):
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862

Modifications:
Participates in complexes:
In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: