Identifiers
K(lysine) acetyltransferase 5
HUGO:KAT5, HGNC:5275, ENTREZ:10524, UNIPROT:Q92993

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / HR 
 Cell Cycle DNA Repair   / FANCONI 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 

References
PMID:12551922, PMID:11927554, PMID:21574959, PMID:18085520
synonym:TIP60

References
ce_re166( Cell Cycle DNA Repair  ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080

1. TIP60*@Nucleus

1. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus
2. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus

1. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@Nucleus + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus + BRCA2@Nucleus + NBS1*|​S343_pho@Nucleus + RAD51@Nucleus + PCNA@Nucleus + H2AFX|​S139_pho|​ubi@Nucleus + TIP60*@Nucleus → BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus
2. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus → BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@Nucleus

1. gHR_DNA_st2*@Nucleus → gHR_DNA_st3*@Nucleus
2. gFanconi_DNA_st4*@Nucleus → gHR_DNA_st2*@Nucleus
3. ATM|​hm2@Site of DNA damage → ATM|​pho|​K3016_ace@Site of DNA damage