Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:H2AFX:NBS1*:PCNA:RAD51:TIP60*
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / HR
Cell Cycle DNA Repair / FANCONI
References
The complex participates in the HR and S-checkpoint
PMID:12239151, PMID:19686080
For Fanconi
PMID:19622404
The complex is considered to be the actual repair structure of the pathway.
MODULE:G1_CC_PHASE
MODULE:S_CC_PHASE
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
ce_re166( Cell Cycle DNA Repair ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
ce_re248( Cell Cycle DNA Repair ):
Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:H2AFX:NBS1*:PCNA:RAD51:TIP60*
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / HR
Cell Cycle DNA Repair / FANCONI
References
The complex participates in the HR and S-checkpoint
PMID:12239151, PMID:19686080
For Fanconi
PMID:19622404
The complex is considered to be the actual repair structure of the pathway.
MODULE:G1_CC_PHASE
MODULE:S_CC_PHASE
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
ce_re248( Cell Cycle DNA Repair ):
ce_re136( Cell Cycle DNA Repair ):
Regulation of HR DNA repair foci formation regulation by UBc13:
PMID:17349954
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair
PMID:22771115
ce_re165( Cell Cycle DNA Repair ):
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
+ BRCA1|S988_pho|S1387_pho|S1423_pho|S1497_pho|S1524_pho|active@Nucleus + BRCA2@Nucleus + NBS1*|S343_pho@Nucleus + RAD51@Nucleus + PCNA@Nucleus + H2AFX|S139_pho|ubi@Nucleus + TIP60*@Nucleus → BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
→ BRCA1:BRCA2:FANCD2|pho:FANCI|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus