Identifiers
NAME:MRE11*:NBS1*:RAD50
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / S_PHASE_CHECKPOINT
Cell Cycle DNA Repair / G2_M_CHECKPOINT
Cell Cycle DNA Repair / HR
Cell Cycle DNA Repair / A_NHEJ
References
PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292
Double strand breaks sensor. MRN complex association is a first event after the DNA damage
PMID:16531125, PMID:17303408, PMID:16163361
For S-phase checkpoint
PMID:19793801, PMID:11850621
ce_re91( Cell Cycle DNA Repair ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.
ce_re36( Cell Cycle DNA Repair ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
ce_re97:( Cell Cycle DNA Repair ) PMID:17303408, PMID:16163361, PMID:15964794
ce_re105( Cell Cycle DNA Repair ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737
ce_re113:( Cell Cycle DNA Repair ) PMID:18171670
ce_re115( Cell Cycle DNA Repair ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
ce_re156( Cell Cycle DNA Repair ):
MRN complex co-locolises at the FA foci and modulates propagation of ICL repair by Fanconi PMID:15136767, PMID:19622404
RPA is required for the replication fork block and remodeling toward DNA repair:
PMID:19622404
For role of SNM1B in Fanconi and S-phase checkpoint
PMID:18469862
ce_re162( Cell Cycle DNA Repair ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404
ce_re165( Cell Cycle DNA Repair ):
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
ce_re187( Cell Cycle DNA Repair ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
ce_re206( Cell Cycle DNA Repair ):
Phosphorylation of NBS1 bt ATR in responce to crosslink-activation of S phase checkpoint
PMID:15136767
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop cell cycle propagation:
+ MRE11*:NBS1*|S343_pho:RAD50@Nucleus + PARP1|PolyADPribose_unk|pho:PARP2|unk|pho@Nucleus → BRCA1:CTIP*|emp|S372_pho|T847_pho|S267_pho|BRCA1-dep_ubi:MRE11*:NBS1*|S343_pho:PARP1|PolyADPribose_unk|pho:PARP2|unk|pho:RAD50@Nucleus
+ MRE11*:NBS1*|S343_pho:RAD50@Nucleus + ATR|pho|active@Nucleus → ATR|pho:FANCD2|K561_ubi|pho:MRE11*:NBS1*|S343_pho:RAD50@Nucleus
+ RAD50@Nucleus + NBS1*|S343_pho@Nucleus → MRE11*:NBS1*|S343_pho:RAD50@Nucleus
+ MRE11*:NBS1*|S343_pho:RAD50@Nucleus → ATM|S1981_pho|S367_pho|S1893_pho:MRE11*:NBS1*|S343_pho:RAD50@Nucleus
→ gA_NHEJ_DNA_st2*@Nucleus
→ S phase@Nucleus
→ gFanconi_DNA_st3*@Nucleus
→ gFanconi_DNA_st4*@Nucleus
→ gHR_DNA_st2*@Nucleus
→ FANCD2|pho@Nucleus
→ gSSA_DNA_st2*@Nucleus
→ ATM|S1981_pho|S367_pho|S1893_pho|active@Nucleus