Reaction state_transition ce_re165
gFanconi_DNA_st4*@Nucleus
→ gHR_DNA_st2*@Nucleus
Reaction regulators:
- Catalysis
- ce_s1000
- BRCA2:FANCC:FANCG|S7_pho:XRCC3@Nucleus
- MRE11*:NBS1*|S343_pho:RAD50@Nucleus
- BRCA1:BRCA2:FANCD2|pho:FANCI|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
- Modulation
- BRCA1:BRCA2:FANCD2|pho:FANCI|pho:FANCJ*:FANCN*@Nucleus
- FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:POLN@Nucleus
References
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862