Identifiers
proliferating cell nuclear antigen
HUGO:PCNA
HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004
HUGO:PCNA HGNC:8729 ENTREZ:5111 UNIPROT:P12004 GENECARDS:PCNA REACTOME:97870 ATLASONC:PCNAID41670ch20p12 WIKI:PCNA
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / NER
Cell Cycle DNA Repair / BER
Cell Cycle DNA Repair / MMR
Cell Cycle DNA Repair / TLS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
References
PMID:14624239, PMID:1974050
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013
NATURAL_KILLER
CASCADE:NKP44
PMID:23414611, PMID:22021614
Proliferating cell nuclear antigen (PCNA), which is overexpressed by cancer cells, has been reported as an inhibitory ligand of NKp44.
PMID:11756412
References
ce_re247( Cell Cycle DNA Repair ):
De-ubiquitination of PCNA serves a negative loop for inactivation of TLS
PMID:16531995
ce_re8( Cell Cycle DNA Repair ):
GADD45 modulated and causes complex formation APE:PCNA. GADD is rgulated by p53:
PMID:17599061, PMID:23485469
ce_re24:( Cell Cycle DNA Repair ) PMID:22973052
ce_re166( Cell Cycle DNA Repair ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
ce_re168( Cell Cycle DNA Repair ):
PMID:18157158
Ubiquitination of PCNA by RAD6-RAD18 increases affinity of PCNA to POLH and makes switch from PCNA-POLD to PCNA-POLH and stops translation and initiates TLS pathway
PMID:15280666, PMID:18498753
ce_re181( Cell Cycle DNA Repair ):
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833, PMID:18157158, PMID:19851286
ce_re254( Cell Cycle DNA Repair ):
GADD45 interacts with PCNA and activates NER-only Global(GG-NER):
PMID:19652693, PMID:10779360
References
ce_re181( Cell Cycle DNA Repair ):
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833, PMID:18157158, PMID:19851286
ce_re114( Cell Cycle DNA Repair ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
PMID:19217833
ce_re220( Cell Cycle DNA Repair ):
Stalled replication fork is mostly induced by ICLs
+ PCNA@Nucleus + POLE*@Nucleus + POLD*@Nucleus + PARP1|PolyADPribose_unk|pho@Nucleus + RFC*@Nucleus → PARP1:PCNA:POLB:POLD*:POLE*:RFC*@Nucleus
+ RPA1:RPA2:RPA3@Nucleus + PCNA@Nucleus + RFC*@Nucleus → EXO1:PCNA:RFC*:hMutL*:hMutS*@Nucleus
+ BRCA1|S988_pho|S1387_pho|S1423_pho|S1497_pho|S1524_pho|active@Nucleus + BRCA2@Nucleus + NBS1*|S343_pho@Nucleus + RAD51@Nucleus + PCNA@Nucleus + H2AFX|S139_pho|ubi@Nucleus + TIP60*@Nucleus → BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
→ PCNA|K164_ubi@Nucleus
+ POLK@Nucleus + REV1@Nucleus → PCNA|K164_ubi:POLK:REV1@Nucleus
+ POLI@Nucleus + REV1@Nucleus → PCNA|K164_ubi:POLI:REV1@Nucleus
+ REV1@Nucleus → PCNA|K164_ubi:REV1@Nucleus
+ POLZ*@Nucleus → PCNA|K164_ubi:POLZ*@Nucleus
→ PCNA|K164_don|K127_don@Nucleus
→ PCNA|K164_ubi|ubi|ubi|ubi@Nucleus
+ PCNA@Nucleus → CTIP*|emp:PCNA@Nucleus
+ POLD*@Nucleus + RFC*@Nucleus + PCNA@Nucleus + CHTF18@Nucleus + POLK@Nucleus + XRCC1|pho@Nucleus + ce_s3289 → CHTF18:PCNA:POLD*:POLE*:POLK:RFC*:RPA2|pho:XRCC1|pho@Nucleus
+ FEN1@Nucleus + WRN@Nucleus → FEN1:PCNA:WRN@Nucleus
→ PCNA@Nucleus
→ BRCA1:BRCA2:FANCD2|pho:FANCI|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
+ LIG1@Nucleus + PARP1|PolyADPribose_unk|pho@Nucleus → LIG1:PARP1|PolyADPribose_unk|pho:PCNA@Nucleus
+ PCNA@Nucleus → GADD45A:PCNA@Nucleus
+ CLSPN|pho@Nucleus + PCNA|K164_ubi@Nucleus + ATRIP:ATR|pho@Nucleus + CHEK1|pho|active@Nucleus → ATRIP:ATR|pho:CHEK1|pho:CLSPN|pho:PCNA|K164_ubi:TIM1*@Nucleus
+ PCNA|K164_ubi@Nucleus + POLH@Nucleus → PCNA|K164_ubi:POLH:REV1@Nucleus
+ APE*|Thr233_pho|ubi@Nucleus + PCNA@Nucleus + WRN@Nucleus → APE*|Thr233_pho|ubi:Mg2+:PCNA:WRN@Nucleus
→ DNA synthesis@Nucleus
+ p21CIP1*@Nucleus → su_akt1_s_akt2_s384
→ Sliding clamp formation@Nucleus
→ PCNA|hm3@Nucleus
+ PCNA|hm3@Nucleus → PCNA|hm3:POLD1:POLD2:POLD3:POLD4@Nucleus
→ PCNA|hm3:POLD1:POLD2:POLD3:POLD4@Nucleus
→ POLD1:POLD2:POLD3:POLD4@Nucleus + PCNA|hm3@Nucleus
→ gBER_M-glyc_DNA_st3*@Nucleus
→ gHR_DNA_st2*@Nucleus
→ G2 phase@Nucleus
→ gTC-NER_GG-NER_DNA_st3*@Nucleus
→ gHR_DNA_st3*@Nucleus
→ gHR_DNA_st7*@Nucleus
→ gHR_DNA_st2*@Nucleus
→ gRepaired_DNA*@Nucleus
→ gLnP_BER_M-glyc_st6*@Nucleus
→ gFanconi_DNA_st1*@Nucleus
→ gGG-NER_DNA_st2*@Nucleus
+ dNTPs@Nucleus → gTC-NER_GG-NER_DNA_st5*@Nucleus
→ gMMR_DNA_st3*@Nucleus
+ dNTPs@Nucleus → gLnP_BER_M-glyc_st4*@Nucleus
→ DNA replicarion@Nucleus
→ gTLS_DNA_st2*@Nucleus
→ gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + 3'ddR5P@Nucleus
→ gLnP_BER_M-glyc_st5*@Nucleus + Modified 2-12 nucl fragment@Nucleus
→ DAP12*|pho:NKp44*@INNATE_IMMUNE_CELL_Membrane
→ gOkazaki Fragments@Nucleus
→ DNA Flap:Okazaki Fragments:RNA primer@Nucleus