Protein BRIT1* map

Identifiers
BRCT-repeat inhibitor of TERT expression 1 (BRIT1), Microcephalin(MCPH1)
HUGO:MCPH1, HGNC:6954, ENTREZ:79648, UNIPROT:Q8NEM0

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / HR  map

References
PMID:20376879, PMID:15220350, PMID:19525936, PMID:18660752

BRIT1*@Nucleus

References
ce_re146( Cell Cycle DNA Repair  map ):
Link between Fanconi and HR:
PMID:15650050, PMID:19686080
ce_re232( Cell Cycle DNA Repair  map ):
p53 inhibits BRCA1 expression, this is a negative loop as response to the up-regulation and stabilization of p53 by BRCA1:
PMID:10884389, PMID:12496474
BRIT1*/E2F1 complex activates BRCA1 and CHEK1 transcription during S-phase and G2/M checkpoints:
PMID:15220350, PMID:18660752
ce_re485( Cell Cycle DNA Repair  map ):
PMID:15220350, PMID:18660752, PMID:20376879

Modifications:
In compartment: Nucleus
  1. BRIT1*@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. BRIT1*:​E2F1@Nucleus map
  2. BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. RAD51:​XRCC2:​XRCC3@Nucleus map + BARD1:​BRCA1@Nucleus map + RAD52@Nucleus map + BRCA2:​DSS1*@Nucleus map + FANCN*@Nucleus map + FANCD2|​K561_ubi|​pho@Nucleus map + BRIT1*@Nucleus map + SFPQ@Nucleus map → map BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@Nucleus map
  2. E2F1@Nucleus map + BRIT1*@Nucleus map → map BRIT1*:​E2F1@Nucleus map
As Catalyser:
  1. gHR_DNA_st2*@Nucleus map → map gHR_DNA_st3*@Nucleus map
  2. gBRCA1@Nucleus map → map rBRCA1@Nucleus map
  3. gCHEK1@Nucleus map → map rCHEK1@Nucleus map