Identifiers
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae), RAD51A
HUGO:RAD51, HGNC:9817, ENTREZ:5888, UNIPROT:Q06609
RAD51-like 1 (S. cerevisiae), RAD51B
HUGO:RAD51L1, HGNC:9822, ENTREZ:5890, UNIPROT:Q86U92
RAD51 homolog C (S. cerevisiae)
HUGO:RAD51C, HGNC:9820, ENTREZ:5889, UNIPROT:O43502
RAD51-like 3 (S. cerevisiae), RAD51D
HUGO:RAD51L3, HGNC:9823, ENTREZ:5892, UNIPROT:O94908
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / G2_M_CHECKPOINT
Cell Cycle DNA Repair / HR
References
PMID:19772495, PMID:16697054, PMID:19847258
References
ce_re166( Cell Cycle DNA Repair ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
+ XRCC2@Nucleus + RAD51@Nucleus → RAD51:XRCC2:XRCC3@Nucleus
+ BARD1:BRCA1@Nucleus + RAD52@Nucleus + BRCA2:DSS1*@Nucleus + FANCN*@Nucleus + FANCD2|K561_ubi|pho@Nucleus + BRIT1*@Nucleus + SFPQ@Nucleus → BARD1:BRCA1:BRCA2:BRIT1*:DSS1*:FANCD2|K561_ubi|pho:FANCN*:RAD51:RAD52:SFPQ:XRCC2:XRCC3@Nucleus
+ BRCA1|S988_pho|S1387_pho|S1423_pho|S1497_pho|S1524_pho|active@Nucleus + BRCA2@Nucleus + NBS1*|S343_pho@Nucleus + RAD51@Nucleus + PCNA@Nucleus + H2AFX|S139_pho|ubi@Nucleus + TIP60*@Nucleus → BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
→ BRCA1:BRCA2:FANCD2|pho:FANCI|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus